Archives

27
Feb

Jeff Benovic, PhD, Receives Discovery of the Year Award for Basic Science

Congratulations to Jeff Benovic, PhD, Thomas Eakins Endowed Professor of Biochemistry & Molecular Biology at Thomas Jefferson University, who was recently honored with the “Discovery of the Year Award for Basic Science” at the 2018 Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. The award was presented …

23
Feb

Christine Eischen, PhD, Receives Prestigious Professorship in Cancer Research

Congratulations to Christine M. Eischen, PhD, who will be invested as the Herbert A. Rosenthal, MD ’56 Professor in Cancer Research this June. Eischen is a professor and Vice Chair in the Department of Cancer Biology at Thomas Jefferson University and co-leader of the Molecular Biology & Genetics Program at the Sidney Kimmel Cancer Center …

5
Jan

Andrew Aplin Named First Recipient of Kalbach-Newton Professorship in Cancer Research

The Sidney Kimmel Medical College (SKMC) at Thomas Jefferson University (TJU) has established a new professorship, made possible through generous donations from the estates of Raymond B. Kalbach and Caroline Newton. Mark Tykocinski, MD, Provost of TJU, and Anthony F. and Gertrude M. DePalma Dean of SKMC, has named Andrew E. Aplin, PhD, one of …

13
Dec

Scott Waldman Named a 2017 Fellow of the National Academy of Inventors

Scott A. Waldman, MD, PhD, Co-Leader of the Gastrointestinal Cancer Program at the Sidney Kimmel Cancer Center at Jefferson and Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been named a Fellow of the National Academy of Inventors (NAI). Waldman is a leader in clinical pharmacology, whose groundbreaking research …

11
Dec

Sidney Kimmel Cancer Center Researchers Receive $1.3 Million from Falk Trust

How can doctors use immunotherapy to develop more effective and durable anticancer therapies? Is it possible to return aggressive cancer cells to a dormant form once they have spread? Those are two questions SKCC researchers Andrew Aplin, PhD, and Emad Alnemri, PhD, will explore with $1.3 million in grants from the Dr. Ralph and Marian …

28
Nov

Decoding the Molecular Mechanisms of Ovarian Cancer Progression

A new study from Sidney Kimmel Cancer Center (SKCC) investigator Christine Eischen, PhD, provided important new insights into the mechanisms contributing to ovarian cancer. The findings were recently published in Nature Communications. Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 …

21
Nov

Cancer Cell Signaling: Selecting the Best Importin for the Job

New research from Sidney Kimmel Cancer Center at Jefferson member Gino Cingolani, PhD, recently provided critical insights into the nuclear import of key signaling proteins, including those involved in tumorigenesis. For a vast array of cellular processes, numerous proteins must be imported and exported from the cell nucleus in a tightly regulated fashion. Typically, proteins that …

17
Nov

Christine Eischen Receives AACR-Bayer Innovation and Discovery Grant

Christine M. Eischen, PhD, Co-Leader of the Molecular Biology & Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has been awarded a 2017 AACR-Bayer Innovation and Discovery Grant. Her grant is entitled, “Using PROTACS to target the Mdm2 oncoprotein.” The Innovation and Discovery Grant offers one-year grants to “meritorious projects that examine important, and …

7
Nov

Sidney Kimmel Cancer Center Grand Rounds Lecture: Elizabeth A. Platz

The Sidney Kimmel Cancer Center at Jefferson is pleased to welcome Elizabeth A. Platz, ScD, MPH, as this week’s lecturer in our Grand Rounds Series. Her talk is entitled “Population Science: Collaborating to Uncover Cancer Etiology While Reflecting on Translation to Reduce Cancer Burden.” Dr. Platz is a Professor, Martin D. Abeloff, MD Scholar in …

19
Oct

Knudsen and Kelly Receive NCI Funding

Two Sidney Kimmel Cancer Center investigators, Karen Knudsen, PhD, and Wm. Kevin Kelly, DO, have been awarded a new R01 grant from the National Cancer Institute to develop more effective therapeutic strategies for advanced prostate cancer. The project builds on previous discoveries from these investigators that identified specific cell cycle alterations in metastatic castrate-resistant prostate cancer and …

13
Oct

Elda Grabocka Recipient of V Foundation Scholar Research Award

Congratulations to Elda Grabocka, PhD, who has been given a prestigious V Foundation Scholar Research Award. Her grant, entitled “Targeting Stress Adaptive Mechanisms as a Strategy for Precision Oncology in Pancreatic Cancer,” is focused on investigating stress granules as predictors of drug resistance and as effective therapeutic targets for the treatment of KRAS-driven pancreatic cancer. …

19
Sep

Molecular Profiling of Key Survival Proteins in B-cell Lymphoma Subtypes

Investigators at the Sidney Kimmel Cancer Center at Jefferson uncovered potential new culprits that contribute to the development and progression of several types of lymphoma. The study was published in a recent issue of Clinical Cancer Research, with co-first authors Drs. Clare M. Adams and Ramkrishna Mitra, along with co-author Dr. Jerald Z. Gong and senior author Christine …

5
May

Getting Personal about Inherited Risk for Prostate Cancer

A new study published in JCO Precision Oncology by lead investigator Veda N. Giri, MD, at the Sidney Kimmel Cancer Center at Jefferson takes an important step in deciphering the genetic landscape contributing to inherited prostate cancer. Genetic Evaluation of Men (GEM) is a study focused on uncovering the genetic contribution to inherited prostate cancer. …

28
Apr

Opening Up Chromatin for Cell Differentiation

Two new studies from the laboratory of Alex Mazo, PhD, at the Sidney Kimmel Cancer Center, along with collaborators from SKCC, the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University, and other institutions, provide new insights into the structure of chromatin and its implications for cellular differentiation.  The new work, appearing in …

25
Apr

New Insights into G Protein-Coupled Receptor Signaling and Regulation

A collaborative study by the laboratories of Jeffrey L. Benovic, PhD,  in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University and the Sidney Kimmel Cancer Center at Jefferson, and Dr. Brian K. Kobilka in the Department of Molecular and Cellular Physiology at the Stanford University School of Medicine provides new insights into a …

16
Dec

Dr. Elda Grabocka Returns to her Jefferson Roots

Elda Grabocka, PhD, feels she is back home. Dr. Grabocka, assistant professor of Cancer Biology at the Sidney Kimmel Cancer Center at Jefferson, recently authored a study: “Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Grabocka and her colleagues found that the same signal that drives aggressive growth in a deadly cancer cell …

20
Sep

Tissue around tumor holds key to fighting triple negative breast cancer

A natural substance found in the surrounding tissue of a tumor may be a promising weapon to stop triple negative breast cancer from metastasizing. A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of tumor …

26
Apr

Scott Waldman Awarded CURE Grant to Move Colon Cancer Test Closer to Commercialization

Scott Waldman, M.D., Ph.D., Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been awarded a Commonwealth Universal Research Enhancement (CURE) grant for almost $750,000 to help advance a molecular diagnostic test for colon cancer into commercialization. Such a test would better detect recurrence in a group of colon cancer …

29
Mar

Dr. Leonard Gomella, Program Director for IPCC in New York

Leonard G. Gomella, M.D., FACS, Chair of Urology at Thomas Jefferson University Hospital and Director of Clinical Affairs at the Kimmel Cancer Center at Jefferson, will serve as the Program Director for the Fifth Annual Interdisciplinary Prostate Cancer Congress (IPCC) at the New York Marriott East Side in New York City on March 31. This …

20
Mar

Biomarker Links Clinical Outcome with New Model of Lethal Tumor Metabolism

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells.  Their findings were published online March 15 in Cell Cycle. To validate the prognostic value of the biomarker, …

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