How Aging Normal Cells Fuel Tumor Growth and Metastasis

It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of …


Biomarker Links Clinical Outcome with New Model of Lethal Tumor Metabolism

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells.  Their findings were published online March 15 in Cell Cycle. To validate the prognostic value of the biomarker, …


New “Achilles’ Heel” in Breast Cancer: Tumor Cell Mitochondria

Researchers at the Kimmel Cancer Center at Jefferson have identified cancer cell mitochondria as the unsuspecting powerhouse and “Achilles’ heel” of tumor growth, opening up the door for new therapeutic targets in breast cancer and other tumor types. Reporting in the online Dec.1 issue of Cell Cycle, Michael P. Lisanti, M.D., Ph.D., Professor and Chair …


Leukemia Drug Reverses Tamoxifen-Resistance in Breast Cancer Cells

Taking a leukemia chemotherapy drug may help breast cancer patients who don’t respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. Interestingly, researchers found that tamoxifen combined with dasatinib, a protein-tyrosine kinase inhibitor, reverses the chemo-resistance caused by cancer-associated fibroblasts in the surrounding tissue by …


“How & Why” Cancer Cells Eat Us Alive

Four key studies now propose a new theory about how cancer cells grow and survive, allowing researchers to design better diagnostics and therapies to target high-risk cancer patients.  These studies were conducted by a large team of researchers at Thomas Jefferson University’s Kimmel Cancer Center.


KCC American Cancer Society Research Symposium

The Kimmel Cancer Center at Jefferson hosted the 2nd Annual American Cancer Society Research Symposium: Celebrating the ACS Institutional Research Grant at KCC on April 16, 2010. Dr. Pestell welcomed members of the KCC and TJU community and the American Cancer Society. Michael Lisanti, MD, PhD was the Keynote Speaker presenting “The Reverse Warburg Effect: …


Stromal Biomarker Predicts Advanced Prostate Cancer

The same biomarker was previously identified as a prognostic factor for breast cancer The absence of a stromal protein called caveolin-1 appears to be a marker for advanced prostate cancer and metastasis, researchers from the Kimmel Cancer Center at Jefferson and Harvard Medical School reported in Cell Cycle. There was an abundance of stromal caveolin-1 …


New Universal Breast Cancer Marker Predicts Recurrence

The marker appears to be widely applicable to all breast cancer patients, regardless of other established prognostic indicators Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, …


Kimmel Cancer Center Scientist Elected to Interurban Clinical Club

Michael Lisanti, M.D., Ph.D., has recently been elected membership to the Interurban Clinical Club. This prestigious club was founded by Sir William Osler in 1905 for the purpose of exchanging ideas and fellowship among medical teachers in some of the leading Eastern medical schools. Dr. Lisanti, joins existing members of the Interurban Clinical Club, Dr. …


Kimmel Cancer Center Scientist Named Editor-in-Chief of Prestigious Pathology Journal

Renowned cell biologist Michael P. Lisanti, M.D., Ph.D., the Margaret Q. Landenberger Professor in Breast Cancer Research at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson in Philadelphia, has been named Editor-in-Chief of The American Journal of Pathology (AJP). His term begins in July. Dr. Lisanti, who serves as …


Jefferson Establishes New Center to Study Stem Cells and Regenerative Medicine

Thomas Jefferson University has established a new center to study the biology, behavior and the potential medical uses of adult stem cells in a variety of diseases, including neurological disease and cancer. The Jefferson Stem Cell Biology and Regenerative Medicine Center will be directed by renowned cell biologist Michael P. Lisanti, M.D., Ph.D., professor of …