Archives

18
Aug

Colorectal Cancer Metastasis: A Game of Clones

Colorectal cancer is highly prevalent worldwide, and metastasis of colorectal cancer to distant sites accounts for ~90% of the mortality associated with this disease. Researchers at the Sidney Kimmel Cancer Center at Jefferson (SKCC), along with collaborators at several other institutions, tracked genomic changes that occur as colorectal tumors progress and metastasize to distant sites …

15
Mar

RNA-Regulated Mechanism Validated as a Target in GI Tract Cancers

Investigators from the Sidney Kimmel Cancer Center at Jefferson, Thomas Jefferson University, and Drexel University have uncovered a critical regulatory mechanism involved in pancreatic and colorectal cancer progression. The study results were recently published in Molecular Cancer Research. The researchers investigated the role of the RNA-binding protein HuR (also known as ELAVL1) in gastrointestinal (GI) …

31
May

ASCO: Younger Colon Cancer Patients Have Worse Prognosis at Diagnosis, Yet Better Survival

Younger patients with colorectal cancer were more likely to present advanced stage tumors at diagnosis and metastasize much sooner, yet had better than or equal survival to patients 50 and older, according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract #3621, Monday, June 4, 8:00 AM …

7
May

Dr. Ronald Myers selected to chair Expert Working Group discussion

Ronald Myers, Ph.D., Professor of Medical Oncology and Director of the Division of Population Science at Thomas Jefferson University, has been selected to chair an Expert Working Group discussion at the World Endoscopy Organization meeting on May 18, 2012. The discussion entitled “Improving Population Engagement in Screening” is being held ahead of the DDW Conference …

26
Aug

A Tumor Suppressor May Also Fight Obesity

The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country‚Äôs biggest pandemics: obesity. Reporting in the August 25 online issue of the Journal of Clinical Investigation, Scott Waldman, M.D., Ph.D., chairman …

16
Feb

Shifting a paradigm: A molecular approach to staging colorectal cancer

A quantitative, molecular analysis of lymph nodes in patients deemed colorectal cancer-free was found to be an effective predictor of recurrence, according to a study from researchers at the Kimmel Cancer Center at Jefferson and published online Feb 9. in Clinical Cancer Research. Recurrence occurs in about 25 percent of node-negative patients (pN0), suggesting that …