Archives

4
Aug

Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer

New research from investigators at the Sidney Kimmel Cancer Center at Jefferson provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. The study was recently published online in Cancer Research. The research team studied the role of an RNA-binding protein termed HuR in influencing the …

11
Jul

Understanding Chemotherapy Resistance in Pancreatic Cancer

A collaborative study involving Sidney Kimmel Cancer Center at Jefferson (SKCC) investigators, together with colleagues from the University of California at San Diego, has provided important insights into how pancreatic cancer cells are able to resist the effects of chemotherapeutic agents. The new study, published in Cancer Research, was led by senior author Jordan Winter, MD, FACS, Associate Professor of …

23
Jun

Important New Insights into Key Regulatory Pathway for Cancer Cell Survival

New research from the laboratory of Christine Eischen, PhD, Co-Leader of the Molecular Biology and Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has revealed a previously unappreciated feature of a well-known cell survival mechanism with potentially important implications for the treatment of some cancers. The study, recently published in Cancer Research, focuses on the …

17
Feb

Researchers Build Pan-Cancer Biomarker Tool to Categorize Multiple Cancer Types

Researchers at the Sidney Kimmel Cancer Center at Jefferson recently discovered that isomiRs (small non-coding RNA molecules produced in a cell) are powerful enough to accurately classify samples that can belong to 32 types of cancer. The research was published in the journal Nucleic Acids Research. Work in recent years has revealed that microRNAs (miRNAs), small …

16
Dec

Dr. Elda Grabocka Returns to her Jefferson Roots

Elda Grabocka, PhD, feels she is back home. Dr. Grabocka, assistant professor of Cancer Biology at the Sidney Kimmel Cancer Center at Jefferson, recently authored a study: “Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Grabocka and her colleagues found that the same signal that drives aggressive growth in a deadly cancer cell …