Left to Right: Hushan Yang, Larry Slagle, Samantha Sabin-Rex, Amy Leader, Daneen Baird, Nancy Hodgson, and Marja Nevalainen
The Kimmel Cancer Center at Jefferson hosted the 3rd Annual ACS-IRG Luncheon on June 16, 2010. The 2010 Pilot Project recipients are Nancy Hodgson, RN, PhD of the Jefferson Center for Applied Research in Aging and Health, Amy Leader, DrPh, MPh and Hushan Yang, PhD, both of the department of Medical Oncology. Read more…
Dr. Richard Pestell and Craig Kaplan
Dr. Richard Pestell accepts a $10,000 check from Craig Kaplan, MilkBoy Communications, on behalf of Dietz and Watson for Jon Runyan’s “Score for the Cure” Golf Tournament. The tournament last year was a great success. To date, they have raised nearly $1,000,000 in the fight against prostate cancer.
The sixth annual Jon Runyan “Score for The Cure” will be held on Tuesday, September 21, 2010.
This annual fundraiser is co-sponsored by Dietz & Watson and Pacific American Securities. This event promises to be a fun filled event featuring past and present members of the Philadelphia Eagles as well as other area professional athletes. The proceeds will go directly to helping cancer research at the Kimmel Cancer Center at Jefferson.
The Quintin Foundation hosted their 4th Annual Martini Tasting Event on Sunday April 18, 2010 from 2-5 pm at Steve and Cookies, 9700 Amhearst Avenue in Margate. The event featured all of the latest trends in top shelf vodka flavors as well as a variety of beers which will be paired with an assortment of delicious foods, live music from acoustic guitar player, Tony Pontari, and a silent auction. The proceeds benefit the cancer programs, research, and treatments at the Kimmel Cancer Center at Jefferson. For more information about the Quintin Foundation please see their home page
Celebration of Life
On Wednesday, June 9th, 2010, the Kimmel Cancer Center will hold it’s 11th annual Celebration of Life event. This Celebration of Life honors and celebrates the lives of all cancer survivors and the people that care about them. For more info about the Celebration of Life Event please see this page
Drs. Edward C. Bradley, Benjamin S. Carson and Raymond C. Grandon were awarded a Doctor of Science honorary degree from Thomas Jefferson University at the Jefferson Medical College, Jefferson College of Graduate Studies and Jefferson School of Population Health Commencement ceremony on May 24, 2010 at the Kimmel Center for the Performing Arts. Dr. Carson was also the keynote speaker. From more information about the 2010 honorees please see this page
Dr Richard Pestell, Mrs. Nataliia Pestell, Dr. Benjamin Carson, Mrs. Candy Carson, Mr Kenneth Boone and Mrs. Penelope Boone
A reception to celebrate Dr. Adam Dicker’s appointment as Chairman of Radiation Oncology was held in the Hamilton Building on Wednesday May 26, 2010. For more about Dr. Dicker’s appointment please go here
Dr. Erk Knudsen
Dr. Erik Knudsen, the KCC, Deputy Director for Research and Professor of Cancer Biology, has accepted the invitation to become the Chair of the Tumor Cell Biology Study Section of NIH. This is an important appointment in the realm of NIH funding for cancer research, and as the official letter from NIH states “The skill and leadership offered by the chairperson determine to a significant extent the effectiveness and efficiency of the review group.” The Kimmel Cancer Center is pleased to note the national recognition of Dr. Knudsen’s standing in the cancer research community that is implicit in being appointed as Chair of a key NIH study section.
Joy Soleiman, KCC Clinical Administrator and Oncology Social Workers, Katie Noble and Bonnie Crouthamel attended the Wellness Community of Philadelphia 12th annual “Evening in the Park: awards dinner. The Kimmel Cancer Center at Jefferson was a supporting sponsor for the evening. To learn more about the The Wellness Community please visit http://www.twcp.org/ .
Professor Robert Thomas
Professor Robert Thomas, Chair of the Victorian Cancer Agency, will tour the Kimmel Cancer Center on June 11. 2010.
Professor Robert Thomas was appointed as the new Chair of the Victorian Cancer Agency by the Victorian Minister for Health, the Hon. Daniel Andrews.
Professor Thomas is the Chief Clinical Advisor for Cancer in the Department of Health, and has a strong track record of working with government in strategic planning for cancer control. As a practicing surgical oncologist and former Chair of the Clinical Services Working Group of the Ministerial Task Force for Cancer, Professor Thomas is uniquely qualified to assist in the achievement of the Agency’s goal of bridging the gap between research and clinical practice.
Professor Thomas will work with the Consultative Council of the Victorian Cancer Agency, supported by CEO Michael Wright and a dedicated team of project staff, to achieve the targets set out for the Agency in Victoria’s Cancer Action Plan, including increasing patient access to clinical trials, developing a cancer research strategy for Victoria and investing in translational research programs and workforce.
Dr. Marja Nevalainen
Researchers from the Kimmel Cancer Center at Jefferson have found that Stat5, a signaling protein previously found to be key to survival of prostate cancer, is also involved in metastasis.
Their study, published in the online edition of Endocrine-Related Cancer, demonstrates in both laboratory and animal models that nuclear Stat5 over-expression leads to a deadly spread of the cancer. They add that their work with mice was unique in that it was the first time Stat5 was associated with prostate cancer metastasis processes in an animal model.
Adam P. Dicker, M.D., Ph.D.
Adam P. Dicker, M.D., Ph.D., has been appointed chairman of the department of Radiation Oncology at Jefferson Medical College of Thomas Jefferson University. Dr. Dicker is an international authority in radiation oncology, drug development, and the treatment of prostate cancer and brain tumors.
Dr. Dicker co-leads the Radiation Research and Translational Biology Program at the Kimmel Cancer Center at Jefferson. In addition, he serves as director of the Christine Baxter Research Laboratory for Experimental Cancer Therapies at Jefferson Medical College. He has been a principal investigator of a significant number of “first in human” developmental therapeutic trials involving novel signal transduction agents and radiation therapy.
The Ladies of Port Richmond held their 6th Annual Port Richmond Breast Cancer Walk. The Walk was held at Monkiewicz Playground – Richmond St and Allegheny Ave. For more details about the Ladies of Port Richmond go to http://ladiesofportrichmond.com/
Dr. Andrew Aplin, Ethan Abel, Gary Safko and Dr. Richard Pestell
Graduate student Ethan Abel has been awarded a Research Scholar Award from the Joanna M. Nicolay Melanoma Foundation. Twenty-four candidates were evaluated for the award.
Ethan Abel, a graduate student working with Andrew Aplin, PhD, in the Kimmel Cancer Center, has received a $10,000 Research Scholar Award from the Joanna M. Nicolay Melanoma Foundation.
The primary objective of the Joanna M. Nicolay Melanoma Foundation is to give recognition and support to outstanding graduate students and their institutions that are actively involved in melanoma research. Melanoma is the deadliest form of skin cancer.
Ethan’s research will focus on the mutations in a protein called BRAF. Mutant B-RAF alters the expression of other genes in melanocytes to promote uncontrolled growth, resistance to death, and spreading beyond the confines of the skin. One gene that is suppressed by mutant B-RAF is called FOXD3, which functions as a cellular switch by turning the expression of genes on and off as needed. Ethan’s research will seek to determine how FOXD3 induces a growth arrest in melanoma cells, how B-RAF suppresses FOXD3 expression, and what factors can induce its expression. A further understanding of the role and regulation of FOXD3 in melanoma may lead to novel therapies for treating the disease.
Also pictured: Gary Safko, President, Joanna M. Nicolay Melanoma Foundation and Dr. Richard Pestell, Director, Kimmel Cancer Center
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The role of genes and proteins in cancer control is well known, but now researchers at Jefferson’s Kimmel Cancer Center have found a cluster of microRNA (miRNA) molecules that act to suppress the invasive spread of breast cancer.
MiRNAs are non-coding small RNA molecules found in wide areas of the genome that, either singly or in clusters, regulates gene expression. Links between dysfunctional miRNA and human disease have only recently been made.
Dr. Richard Pestell
Richard G. Pestell, M.D., Ph.D., FACP, FRACP, Director of the Kimmel Cancer Center at Jefferson, was honored with the R. Douglas Wright Medallion and delivered the R. Douglas Wright Lecture at the University of Melbourne in Australia. The award is given in the areas of science, literature, economics and politics. Prior recipients include Sir James Tait, co-discoverer of aldosterone.
Dr. Andrea Morrione
Bladder cancer often becomes aggressive and spreads in patients despite treatment, but now researchers at the Kimmel Cancer Center at Jefferson have identified a protein they believe is involved in pushing tumors to become invasive – and deadly.
“We have found that IGF-IR is a critical regulator of motility and invasion of bladder cancer cells, and this could offer us a novel molecular target to treat patients with this cancer in order to prevent metastasis,” says the lead investigator, Andrea Morrione, Ph.D., a research associate professor of Urology at Jefferson Medical College, and director of Urology Research, Kimmel Cancer Center.
Researchers at the Kimmel Cancer Center at Jefferson have discovered how a powerful tumor suppressor called DACH1 works – a finding that explains why restoring its lost function in cancer cells pushes them to become normal again.
In the March 29 online early edition of the Proceedings of the National Academy of Sciences (PNAS), the researchers say that DACH1 is a potent transcription factor whose protein binds to and forms a lock, of sorts, that stops more than 1,500 human genes from being activated. Some of these genes have been previously shown to promote cancer. When DACH1 isn’t around the expression levels of these genes increase because another well-known cancer promoting protein, forkhead, slots into the unlocked genes and turns them on.
Dr. Richard Pestell and Ambassador Kim Beazley
The Honorable Kim Beazley, Ambassador to United States of America, joins the Kimmel Cancer Center Board.
Mr Beazley was elected to the Federal Parliament in 1980 and represented the
electorates of Swan (1980-96) and Brand (1996-2007).
Mr Beazley was a Minister in the Hawke and Keating Labor Governments (1983-96) holding, at various times, the portfolios of Defence, Finance, Transport and Communications, Employment Education and Training, Aviation, and Special Minister of State. He was Deputy Prime Minister (1995-96) and Leader of the
Australian Labor Party and Leader of the Opposition (1996-01 and 2005-06). Mr Beazley served on parliamentary committees, including the Joint Intelligence Committee and the Joint Foreign Affairs, Defence and Trade Committee.
After his retirement from politics in 2007, Mr Beazley was appointed Winthrop Professor in the Department of Politics and International Relations at the University of Western Australia. In July 2008 he was appointed Chancellor of the Australian National University, a position he held until December 2009.
In 2009, Mr Beazley was awarded the Companion of the Order of Australia for service to the Parliament of Australia through contributions to the development of government policies in relation to defence and international relations, and as an advocate for Indigenous people, and to the community.
Mr Beazley was born in Perth. He completed a Bachelor of Arts and Master of Arts at the University of Western Australia. He was awarded the Rhodes Scholarship for Western Australia in 1973 and completed a Master of Philosophy at Oxford University. He is married and has three daughters.
Dr. Leonard G. Gomella
Leonard G. Gomella, MD, FACS have been appointed Chair-Elect for the American Society of Clinical Oncology (ASCO) 2011 Genitourinary Cancers Symposium in Orlando, Florida.
The Kimmel Cancer Center at Jefferson hosted the 2nd Annual American Cancer Society Research Symposium: Celebrating the ACS Institutional Research Grant at KCC on April 16, 2010. Dr. Pestell welcomed members of the KCC and TJU community and the American Cancer Society. Michael Lisanti, MD, PhD was the Keynote Speaker presenting “The Reverse Warburg Effect: Stromal-Epithelial Metabolic Coupling in Cancer”. After the Keynote Address Dr. Nevalainen introduced the IRG Pilot Project recipients for 2009 who presented the results of their research: Jonathan Brody, PhD of the Department of Surgery, “The HuR Protein Performs Well Under Stress: Implications for the Treatment of Pancreatic Cancer”; Jun Li, PhD from the Department of Radiation Oncology, “Ultrasound-encoded Optical Imaging” and Janice Walker, PhD of the Department of Pathology, Anatomy & Cell Biology, “Lessons from Wound Healing for Understanding Mechanisms of Cancer Progression”. Representing the American Cancer Society were Daneen Baird, Wan Ling Hung, Kate Mastalski, and Larry Slagle.