Kimmel Cancer Center Scientist Named Editor-in-Chief of Prestigious Pathology Journal


Dr. Michael Lisanti

Dr. Michael Lisanti

Renowned cell biologist Michael P. Lisanti, M.D., Ph.D., the Margaret Q. Landenberger Professor in Breast Cancer Research at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson in Philadelphia, has been named Editor-in-Chief of The American Journal of Pathology (AJP). His term begins in July.

Dr. Lisanti, who serves as director of the newly established Jefferson Stem Cell Biology and Regenerative Medicine Center, is also professor of Cancer Biology at Jefferson Medical College.

Few cell biologists can point to research with such wide-reaching implications as Dr. Lisanti, who is an expert in the field of caveolae and caveolin proteins. These proteins, which play important roles in cell communication, are also involved in the development of a number of diseases and conditions, such as cancer, atherosclerosis, diabetes, Alzheimer’s disease and muscular dystrophy. Dr. Lisanti’s research has focused primarily on caveolin-1, the most abundant and widespread of the caveolin proteins. His work provides the best evidence to date that caveolin-1 functions as a tumor suppressor – that is, it blocks the development of tumors – in mammalian cells.

His group was among the first to create a mouse strain lacking the caveolin-1 gene, establishing a model system to study the role of the loss of caveolin-1 in breast cancer development. His team found that a known mutation in the caveolin-1 gene is present in approximately 19 percent of all breast cancers that are fed by estrogen – so-called “estrogen receptor-positive” cells.

A recipient of many awards and honors, Dr. Lisanti is the 13th most cited scientist in biochemistry and biology in the scientific literature in the last decade. Dr. Lisanti came to Jefferson in 2006 from the Albert Einstein College of Medicine in New York, where he was professor of molecular pharmacology and medicine.

The American Journal of Pathology is published by and serves as the official journal of the American Society for Investigative Pathology (ASIP). In a statement from ASIP, President Mark L. Tykocinski, M.D., summarized the selection process by saying, “Dr. Lisanti’s scientific curiosity and personal dynamism energize those around him, and we are excited by what his vision and creativity can bring to the AJP and to disease pathogenesis research as a whole.”

“We congratulate Michael Lisanti on his well deserved appointment as Editor-in-Chief,” adds Kimmel Cancer Center director Richard Pestell, M.D., Ph.D., chair of the Department of Cancer Biology at Jefferson Medical College. “His widely recognized expertise in a number of fields makes him uniquely qualified for the position.”

The American Journal of Pathology is the top-ranked journal in field of pathology (Source: Thomson’s Journal Citation Reports).