“In the field of radiation oncology, we often assume that the highest dose that the body can tolerate will be most effective at killing cancer,” said senior study author Dr. Robert Den, a researcher at Thomas Jefferson University’s Sidney Kimmel Cancer Center in Philadelphia.
“Our results argue that this may not be the case, at least not with lower-risk prostate cancer patients,” Den added in a university news release.
The researchers reviewed 12 studies that assessed the use of external beam radiation treatment for men with localized prostate cancer. The clinical trials included more than 6,800 patients.
As patients received higher doses of radiation, there was a drop in prostate-specific antigen (PSA) levels, which are used to monitor prostate cancer. However, higher doses of radiation did not lead to lower rates of prostate cancer spreading to other parts of the body or higher survival rates over the long-term.
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