Thomas Jefferson University and the Kimmel Cancer Center are pleased to announce that Karen E. Knudsen, Ph.D., has accepted the position as Deputy Director of Basic Science, and will hold the prestigious Hilary Koprowski Chair in the Department of Cancer Biology.
Dr. Knudsen received her Ph.D. from the University of California at San Diego in 1996, focusing on cell cycle checkpoint control. Her postdoctoral studies with Dr. Webster K. Cavenee at the Ludwig Institute for Cancer Research cultivated a program centered on the mechanisms underlying hormone-dependent cell cycle control.
Dr. Knudsen was recruited to Thomas Jefferson University in 2007 (now a Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology) after a successful career at the University of Cincinnati College of Medicine, where she was a tenured Associate Professor. In addition to her duties as the Deputy Director, Dr. Knudsen also serves as Leader of the Kimmel Cancer Center Biology of Prostate Cancer Program, and Director of the Greater Philadelphia Prostate Cancer Working Group.
Dr. Knudsen’s research interests are dedicated to understanding the mechanisms by which hormone receptor and cell cycle deregulation lead to prostate cancer progression and therapeutic bypass. The overall goal of Dr. Knudsen’s laboratory is to utilize this information for successful development of precision medicine, so as to improve therapeutic outcome and patient care through rational therapy delivery. Her studies identifying tumor suppressor and hormone receptor alterations have uncovered new targets for treating advanced disease, and led to development of biomarker-driven clinical trials.
Dr. Knudsen serves on a multitude of national boards and committees, including those for the American Association for Cancer Research, the Endocrine Society, and the Prostate Cancer Foundation. She has been a Senior Editor for Cancer Research since 2007, is an Associate Editor for Endocrine-Related Cancer, and sits on the editorial boards of Molecular Cancer Therapeutics, the American Journal of Pathology, Molecular Endocrinology, and Oncogene. Most recently, Dr. Knudsen was appointed Editor-in-Chief of Molecular Cancer Research by the American Association for Cancer Research. Dr. Knudsen has received numerous awards for her research, including the Ronald Ross Award for Excellence in Hormone-dependent malignancies from the Pacific Rim Breast and Prostate Cancer Research Organization, and the Richard E. Weitzman Laureate Award from the Endocrine Society.