“Longevity” Protein SIRT1 May Ward Off Precursor to Prostate Cancer

22
Feb

Dr. Richard G. Pestell

Dr. Richard G. Pestell

Researchers from the Kimmel Cancer Center at Jefferson and two other institutions have discovered new evidence that suggests the “longevity” protein SIRT1, known for its life-spanning effects in different species, can inhibit the development of a known precursor to prostate cancer, prostatic intraepithelial neoplasia (PIN).

“Prostate cancer is one of the malignancies that has a very direct relationship to aging,” says Richard G. Pestell, M.D., Ph.D., Director, Kimmel Cancer Center and Chairman of Cancer Biology at Thomas Jefferson University. “And these results provide a direct link for the first time between the onset of prostate cancer and the Sirt1 gene that regulate aging.”

The findings were reported in the February 2011 edition of Cancer Research ( pubmed)  ( JeffNews )