Category Breast Cancer

16
Aug

Dr. Ana María López to Lead Medical Oncology at SKCC Jefferson Health – Washington Township

Ana María López, MD, MPH, joins the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) as the Vice Chair of Medical Oncology and Chief of Cancer Services at the Sidney Kimmel Cancer Center – Washington Township. Dr. López comes from the Huntsman Cancer Institute in Salt Lake City, where she was Director of Cancer Health …

12
Mar

Dan Silver, MD, PhD, Receives “Outstanding Member” Award at Cancer Center Retreat

Congratulations to Dan Silver, MD, PhD, Associate Professor of Medical Oncology and Director of Basic Science and Research in Medical Oncology, for receiving the “Director’s Award – Outstanding Member” at the recent Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. Silver, who is also the leader of …

9
Feb

Adam Berger, MD, FACS, Receives Sidney Kimmel Cancer Center Achievement in Clinical Research Award

Congratulations to Adam Berger, MD, FACS, Vice Chair for Clinical Research, who recently received the “Achievement in Clinical Research Award” at the 2018 Sidney Kimmel Cancer Center (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. The award was presented to Berger by Kevin Kelly, DO, Associate Director of Clinical Research and Leader of the Prostate …

26
Jul

Single-Cell Resolution Mutational Profiling in Breast Cancer

A new study from Sidney Kimmel Cancer Center at Jefferson demonstrated the feasibility of detecting cancer-associated gene mutations in circulating tumor cells (CTC) isolated from patients — providing a powerful new tool for clinicians and cancer researchers. Published in Clinical Cancer Research, the project was led by senior authors Paolo M. Fortina, MD, PhD, and Massimo …

21
Mar

Unite for HER Wellness Day – April 2, 2017

  The Sidney Kimmel Cancer Center at Jefferson encourages Jefferson Hospital System breast cancer patients to participate in the upcoming “Unite for HER Wellness Day” event to be held on Sunday, April 2, 2017. This event will allow breast cancer patients to meet in a small group setting with trained professionals to learn about complementary …

17
Feb

Five Easy Ways to Lower Your Cancer Risk

February is National Cancer Prevention Month. Below are 5 easy ways to help reduce your risk of developing cancer, thanks to Amy Leader, PhD, and Charnita Zeigler-Johnson, PhD, both Assistant Professors in the Department of Medical Oncology.  1. Healthy diet It is well known that a poor diet can lead to being overweight or obese, which …

7
Dec

Jefferson Breast Cancer Researcher Named Margaret Q. Landenberger Professor

Nicole Simone, MD, has been named the Margaret Q. Landenberger Professor. The professorship, which focuses on breast cancer research, was established in 2006 by the Margaret Q. Landenberger Research Foundation. Dr. Simone will be the second holder of the professorship. “Dr. Simone is a cancer research pioneer who has dedicated her entire career to discovering …

9
Mar

Two Drexel University College of Medicine Professors Receive Grants Through Statewide Refunds for Breast Cancer Research Campaign

The Pennsylvania Breast Cancer Coalition recently awarded two Drexel University College of Medicine researchers (and Sidney Kimmel Cancer Center Members) grants from its statewide Refunds for Breast Cancer Research campaign. Alessandro Fatatis, MD, PhD, professor in the Departments of Pharmacology & Physiology and Pathology & Laboratory Medicine, and Mauricio Reginato, PhD, associate professor in the …

7
Jan

Hold Your Breath to Protect Your Heart

A recent article in the Practical Radiation Oncology was highlighted in Eureka Alerts. The research, performed by members of the Department of Radiation Oncology and the Sidney Kimmel Cancer Center of Thomas Jefferson University, indicated the importance of breathing control during radiation therapy for left breast cancer in protecting the heart from radiation exposure. Harriet …

9
Sep

KCC Researchers Awarded $480,000 from Breast Cancer Research Foundation

The Breast Cancer Research Foundation recently announced that Dr. Richard Pestell and Dr. Andrew Quong received unanimous approval for studies in breast cancer, the second most prevalent cancer-related cause of death in women in the United States. Beginning October 1, 2013, Dr. Pestell will receive $240,000 to continue the “Molecular Genetic determinants of Breast Cancer …

23
Aug

Researchers Find New Clues to Treat Rare and Aggressive Inflammatory Breast Cancer

A study led by investigators from Thomas Jefferson University’s Kimmel Cancer Center has discovered molecular clues that may help physicians therapeutically target inflammatory breast cancer (IBC), a highly aggressive form of breast cancer. Their study, reported in the June 21 online issue of Breast Cancer Research and Treatment, identified two molecules (ALK and FAK1) involved in the …

23
Aug

Researchers Discover Molecule That Drives Aggressive Breast Cancer

Recent studies by researchers at Thomas Jefferson University’s Kimmel Cancer Center have shown a gene known to coordinate initial development of the eye (EYA1) is a powerful breast tumor promoter in mice. The gene EYA1 was also shown to be overexpressed in a genetic breast cancer subtype called luminal B. The scientists found that excess …

15
Jul

Ladies of Port Richmond Featured in Inquirer

Mary Louise Leuters is a two-time breast cancer survivor and president of the Ladies of Port Richmond, a local group of breast cancer survivors who have raised over $400,000 for breast cancer research in the last nine years.Nearly 300,000 American women will be diagnosed with breast cancer this year, and 40,000 will die from it, …

12
Feb

Massimo Cristofanilli, M.D., Appointed Director of the Jefferson Breast Care Center

Massimo Cristofanilli, M.D., FACP, an internationally renowned breast cancer researcher and clinician, has been appointed Director of the Jefferson Breast Care Center at the Kimmel Cancer Center (KCC) and Thomas Jefferson University and Hospitals. With more than 25 years of clinical, basic science and educational experience, Dr. Cristofanilli will also serve as Deputy Director of …

12
Feb

Jefferson Opens Calorie Restriction Trial for Early Stage Breast Cancer Patients on Radiation Therapy

Jefferson’s Kimmel Cancer Center will begin a first-of-its-kind clinical trial that uses calorie restriction to help treat early stage breast cancer patients undergoing radiation therapy. Evidence suggests that reducing patients’ calorie intake could help shrink tumors and improve survival because it enhances the effectiveness of radiation therapy, the team explains in a recent review published …

20
Sep

Tissue around tumor holds key to fighting triple negative breast cancer

A natural substance found in the surrounding tissue of a tumor may be a promising weapon to stop triple negative breast cancer from metastasizing. A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of tumor …

26
Jul

Breast Cancer Patients Who Lack RB Gene Respond Better to Neoadjuvant Chemotherapy

Breast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research. Many breast cancer patients undergo neoadjuvant therapy …

14
Jun

How Aging Normal Cells Fuel Tumor Growth and Metastasis

It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of …

13
Jun

HIV Drug May Slow Down Metastatic Triple-Negative Breast Cancer

Researchers at the Kimmel Cancer Center, led by Dr. Richard G. Pestell have discovered that FDA-approved HIV drugs may stop triple-negative breast cancer from spreading to other organs in pre-clinical models. These results were originally reported in Cancer Research. Recent articles about this discovery have also appeared in NewsWise and the Philadelphia Inquirer.

7
Jun

HIV drug may slow down metastatic breast cancer

The HIV drugs known as CCR5 antagonists may also help prevent aggressive breast cancers from metastasizing, researchers from the Kimmel Cancer Center at Jefferson suggest in a preclinical study published in a recent issue of Cancer Research. Such drugs target the HIV receptor CCR5, which the virus uses to enter and infect host cells, and …

3
Apr

AACR: Eliminating the ‘Good Cholesterol’ Receptor May Fight Breast Cancer

CHICAGO— Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson’s Kimmel Cancer Center researchers. In vitro and mouse studies revealed that depletion of the SR-BI resulted in a decrease in breast cancer cell …

20
Mar

Biomarker Links Clinical Outcome with New Model of Lethal Tumor Metabolism

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells.  Their findings were published online March 15 in Cell Cycle. To validate the prognostic value of the biomarker, …

15
Feb

Taxpayers Give Back for Cancer: Jefferson Researcher Awarded ‘Refunds for Research’ Grant

Takemi Tanaka, Ph.D., of Thomas Jefferson University’s School of Pharmacy and the Kimmel Cancer Center, received a $50,000 grant toward her breast cancer research, as part of the Pennsylvania Breast Cancer Coalition’s (PBCC) “Refunds for Breast and Cervical Cancer Research” initiative. The PBCC’s grants are made possible through contributions from state taxpayers who choose to …

7
Feb

Drugs targeting chromosomal instability may fight a particular breast cancer subtype

Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson’s Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of Cancer Biology, have shown in a study published online Feb. 6 in the Journal of Clinical Investigation …

13
Dec

Loss of RB in Triple Negative Breast Cancer Associated with Favorable Clinical Outcome

Researchers at the Thomas Jefferson University Hospital and Kimmel Cancer Center at Jefferson have shown that loss of the retinoblastoma tumor suppressor gene (RB) in triple negative breast cancer patients is associated with better clinical outcomes. This is a new marker to identify the subset of these patients who may respond positively to chemotherapy. Today, …

31
Oct

Gordon Schwartz, M.D., Nominated to National Accreditation Program for Breast Centers Board

Gordon F. Schwartz, MD, MBA, FACS, director of the Jefferson Breast Care Center, will represent the American Society of Breast Disease on the board of the National Accreditation Program for Breast Centers (NAPBC). The NAPBC is a consortium of national, professional organizations dedicated to the improvement of the quality of care and the monitoring of …

29
Sep

Kimmel Cancer Center at Jefferson Celebrates 20 Years of Patient Care and Cancer Discovery

From October forward, the Kimmel Cancer Center at Jefferson (KCC), a National Cancer Institute-designated cancer center, is celebrating 20 years of service to the community and the groundbreaking cancer research from the scientists and physicians who’ve provided an invaluable contribution to medical science and healthcare. “This is truly a milestone for the Kimmel Cancer Center—it’s …

2
Aug

Leukemia Drug Reverses Tamoxifen-Resistance in Breast Cancer Cells

Taking a leukemia chemotherapy drug may help breast cancer patients who don’t respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. Interestingly, researchers found that tamoxifen combined with dasatinib, a protein-tyrosine kinase inhibitor, reverses the chemo-resistance caused by cancer-associated fibroblasts in the surrounding tissue by …

1
Jun

Dr. Karen Knudsen Receives Ron Ross Award

See the Award Announcement for more information about the Award and its latest recipient. The following was abstracted from the announcement. Dr. Karen Knudsen of the Kimmel Cancer Center received the Ron Ross Award at the 5th Pacific Rim Breast and Prostate Cancer Meeting, held in Kingscliff, Australia, May 3-7, 2011. Dr. Ron Ross was …

1
Jun

KCC Research: Cancer Cells Accelerate Aging & Inflammation in Body to Drive Tumor Growth

Researchers at the Kimmel Cancer Center at Jefferson have shed new light on the longstanding conundrum about what makes a tumor grow—and how to make it stop.  Interestingly, cancer cells accelerate the aging of nearby connective tissue cells to cause inflammation, which ultimately provides “fuel” for the tumor to grow and even metastasize. This revealing …

19
May

Marker Identifies Breast Cancer Patients Likely to Respond to Tamoxifen

ER positive breast cancer patients whose tumors have active protein Stat5 have increased likelihood of responding to anti-estrogen therapy PHILADELPHIA—Cancer researchers at the Kimmel Cancer Center at Jefferson and an international team of collaborators have discovered a biomarker in breast cancer that may help identify which women will respond to anti-estrogen therapy. The research appears …

19
Apr

Jefferson Researchers Unlock Key to Personalized Cancer Medicine Using Tumor Metabolism

Identifying gene mutations in cancer patients to predict clinical outcome has been the cornerstone of cancer research for nearly three decades, but now researchers at the Kimmel Cancer Center at Jefferson have invented a new approach that instead links cancer cell metabolism with poor clinical outcome. This approach can now be applied to virtually any …

6
Apr

Kimmel Cancer Center at Jefferson breast cancer symposium features latest in research, treatment

The latest advances in both breast cancer treatment and research – including innovations in diagnostic, surgical, chemotherapy and radiation approaches – will be discussed Friday, April 8, 2011, at a breast cancer symposium at the Kimmel Cancer Center at Jefferson in Philadelphia. The all-day, breast cancer symposium, part of an annual series at the Kimmel …

1
Mar

Radiation Oncology Announcements and Appointments

New faculty: Thomas Jefferson University welcomes two new, seasoned clinicians and researchers to its Department of Radiation Oncology: Nicole Simone, M.D., from the National Institutes of Health’s National Cancer Institute (NCI) and Bo Lu, M.D., Ph.D, from Vanderbilt University. Dr. Simone is a board-certified Radiation Oncologist who has treated mostly patients with breast and head …

15
Feb

Researchers Say Stress Fuels Cancer Growth, Provide Genetic Evidence That Antioxidants Can Help Treat It

Researchers from Jefferson’s Kimmel Cancer Center have genetic evidence suggesting the antioxidant drugs currently used to treat lung disease, malaria and even the common cold can also help prevent and treat cancers because they fight against mitochondrial oxidative stress—a culprit in driving tumor growth. For the first time, the researchers show that loss of the …

11
Feb

New Tumor Tracking Technique for Radiotherapy Spares Healthy Tissue, Could Improve Cancer Treatment

Medical physicists at Thomas Jefferson University and Jefferson’s Kimmel Cancer Center have demonstrated a new real-time tumor tracking technique that can help minimize the amount of radiation delivered to surrounding healthy tissue in a patient—up to 50 percent less in some cases—and maximize the dose the tumor receives. Respiratory and cardiac motions have been found …

18
Nov

2010 Breast Health International Breast Cancer Consensus Conference

On Friday, October 22 through Sunday, October 24, 2010, Jefferson’s Kimmel Cancer Center co-sponsored with the Breast Health International  a Breast Cancer Consensus Conference.  The conference brought leading breast cancer experts from around the world together to discuss Adjuvant Therapy in Stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotyping.

4
Nov

Breast Health International Held Annual Black Tie Gala

Breast Health International, a division of the Foundation for Breast & Prostate Health held it’s annual Black Tie Gala honoring Neiman Marcus and benefiting breast cancer research and development. The event was held on Friday, October 29. 2010 at the Rittenhouse Hotel in Downtown Philadelphia. Music was provided by the Eddie Bruce Band. A silent …

19
Oct

Dr. Mitchell & The KCC Host A Program On Triple Negative Breast Cancer Awareness

On Saturday, October 9th, 2010, Dr. Edith P. Mitchell and the Kimmel Cancer Center hosted a special program about triple-negative breast cancer (TNBC).  TNBC accounts for approximately 15% to 20% of breast cancer diagnoses but has twice the rate of prevalence among young women, particularly pre-menopausal African-American women. This program is designed to increase your …

14
Oct

Dr. Pestell and the Thomas Jefferson University Hospital to be honored by the Susan G. Komen for the Cure

Dr. Richard Pestell, Director of the Kimmel Cancer Center at Jefferson, will receive the “Light of Life” award at the 2010 Susan G. Komen Pink Tie Ball on Saturday, October 16.  Also that evening the “Beacon of Hope” award to the Thomas Jefferson University Hospital  will be accepted by Thomas J. Lewis, President and CEO, …

19
May

Small RNA Molecules Block Breast Cancer from Spreading via Newly Identified Secreted Factor

The role of genes and proteins in cancer control is well known, but now researchers at Jefferson’s Kimmel Cancer Center have found a cluster of microRNA (miRNA) molecules that act to suppress the invasive spread of breast cancer. MiRNAs are non-coding small RNA molecules found in wide areas of the genome that, either singly or …

19
May

Jefferson Scientists Unlock Secret to Powerful Tumor Suppressor That Can Reverse Cancer Progression

Researchers at the Kimmel Cancer Center at Jefferson have discovered how a powerful tumor suppressor called DACH1 works – a finding that explains why restoring its lost function in cancer cells pushes them to become normal again. In the March 29 online early edition of the Proceedings of the National Academy of Sciences (PNAS), the …

14
Apr

Ladies of Port Richmond Annual Breakfast

The Ladies of Port Richmond held their annual Breakfast fund raiser on Sunday, April 11 2010 at St Adalbert’s School Hall (see the photo gallery). The “Breakfast” also served as a kick-off meeting for the 6th Annual Port Richmond Breast Cancer Walk. The Walk will be held on Sunday, May 16 2010 at 10:00 AM …

23
Feb

Ladies of Port Richmond Support Young KCC Investigators

Thanks to the fundraising efforts of the Ladies of Port Richmond, the Kimmel Cancer Center at Jefferson has awarded six junior investigators with funding for the prevention and improved treatment of breast cancer. The titles of the supported submissions were: John Pascal, Ph.D. Novel Mechanisms For Inhibiting The Cellular Functions Of Parp1 For Cancer Treatment …

22
Feb

Prolactin Blocks Oncogene Associated with Poor Prognosis in Breast Cancer

Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive. Publishing in the journal Cancer Research, the researchers discovered that prolactin, a pituitary hormone that normally stimulates breast development and milk production, in fact reduces levels …

2
Feb

Rock the Ribbon Black Tie Event, March 27th, 2010

CKC United will host the inaugural "Rock the Ribbon" black tie event. The event will be held on March 27th, 2010 at The Regal Ballroom in Philadelphia, PA. This black tie ball features a delicious four course meal, complimentary beverages, guest speakers, and top notch live music. The formation of CKC United stems from the …

27
May

Philadelphia Komen Race for the Cure Recap

The Philadelphia Affiliate of the Susan G. Komen Foundation Race for the CURE held their annual Mother’s Day Race on Sunday, May 10th, 2009. The Kimmel Cancer Center at Jefferson sponsored a booth and Team Jefferson also participated in the race. A few photos from the race below. Gallery

21
May

New Universal Breast Cancer Marker Predicts Recurrence

The marker appears to be widely applicable to all breast cancer patients, regardless of other established prognostic indicators Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, …

29
Apr

Ladies of Port Richmond 5th Annual Breast Cancer Walk

View Larger Map A reminder that The Ladies of Port Richmond will be holding their annual Breast Cancer Walk on Sunday, May 17th, 2009. Registration at the walk begins at 8:30 am while the walk starts at 10:00 am. So download the registration form and the pledge form and hit the streets “to increase Breast …

14
Apr

Jefferson’s Kimmel Cancer Center Researchers Receive $6.7 million Grant from Susan G. Komen for the Cure

Researchers from the Kimmel Cancer Center at Jefferson were awarded a Susan G. Komen for the Cure Promise Grant of almost $6.7 million for five years for continued breast cancer research. The project represents a multidisciplinary team of scientists from a consortium that also includes Walter Reed Army Medical Center and DecisionQ Inc. in Washington …

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