Category Prostate Cancer

11
Oct

SKCC Researchers Receive NIH Grant to Study Prostate Cancer Disparities among African Americans

Sidney Kimmel Cancer Center – Jefferson Health (SKCC) researchers have received a planning grant for Specialized Program of Research Excellence (SPORE) to Investigate Cancer Health Disparities (P20 grant) from the National Institutes of Health (NIH) to study a “precision interception approach” to prevent prostate cancer progression among African American men. Grace Lu-Yao, PhD, MPH, Associate …

13
Sep

Sidney Kimmel Cancer Center Enhances Population Science Research with TIPS

Over the last few years, the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) has successfully integrated population science — a field of research focused on improving public health on a broad scale — into its existing five cancer research programs through the creation of a mechanism known as TIPS, short for Transdisciplinary Integration of …

14
Aug

SKCC Director Dr. Karen Knudsen Named Association of American Cancer Institutes’ President-Elect

Karen E. Knudsen, PhD, Enterprise Director of the National Cancer Institute (NCI)-designated Sidney Kimmel Cancer Center– Jefferson Health (SKCC), has been elected vice president/president-elect of the Association of American Cancer Institutes’ (AACI) board of directors. Dr. Knudsen, who has been serving as SKCC enterprise director since 2015, governs cancer research and cancer care across 14 hospitals within …

25
Jul

Sidney Kimmel Cancer Center Announces ACS Institutional Research Grant Recipients

The Sidney Kimmel Cancer Center – Jefferson Health is pleased to announce the most recent recipients of the American Cancer Society Institutional Research Grants. American Cancer Society Institutional Research Grants are awarded to institutions as block grants to provide seed money for newly independent investigators to initiate research projects. The intent of this support is …

25
Jun

From Patient to Supporter: Helping Others Navigate a Cancer Diagnosis

As an Air Force and commercial airline pilot, Pete Lonngren’s top priority had always been safety. So in 2007 when he discovered a swollen lymph node in his neck, he knew he had to follow his instincts and take action for the sake of his health. Lonngren, an Indiana native who has lived in South …

22
May

Understanding Genetic Test Results for Prostate Cancer: Needs for Men Identified

Some prostate cancer patients will need help understanding the complexity of genetic results, a new study finds. As genetic testing for various diseases gains in popularity, researchers are finding that there can be confusion about what the test results really mean, how much they increase a person’s risk of disease, and whether there’s any important …

20
Mar

Wm. Kevin Kelly, DO, Elected as Co-Chair of NCI Steering Committee

Wm. Kevin Kelly, DO, leader of the Prostate Cancer Program and associate director of Clinical Research at the Sidney Kimmel Cancer Center at Jefferson Health (SKCC), has been elected to serve as medical oncology co-chair on the National Cancer Institute (NCI) Genitourinary Cancers Steering Committee (GUSC). The GUSC addresses the design, prioritization, and evaluation of …

6
Mar

Kevin Kelly, DO, Receives “Director’s Award for Impact” at Member Retreat

Congratulations to Wm. Kevin Kelly, DO, Professor of Medical Oncology and Director of the Division of Solid Tumor Oncology, for receiving the “Director’s Award for Impact” at the recent Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. Kelly, who is also the leader of the Prostate Cancer …

31
Jan

Veda Giri, MD, Receives Sidney Kimmel Cancer Center Population Science Award

Congratulations to Veda Nargund Giri, MD, who recently received the “Discovery of the Year Award for Population Science” at the 2018 Sidney Kimmel Cancer Center Member Retreat, held at Citizens Bank Park in Philadelphia. Giri has had long-standing interest in developing the field of genetic counseling and testing for inherited prostate cancer. She is a medical …

14
Dec

New Recommendations Provide Guidance on Genetic Counseling & Testing for Hereditary Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. Now, an international and interspecialty panel of experts convened at the Sidney Kimmel Cancer Center (SKCC) at Jefferson have developed a comprehensive set of recommendations. This consensus statement, published December 13th in the Journal …

5
Dec

Researchers Find Breakthroughs in Understanding Genetic Basis of Aggressive Prostate Cancer

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer. When it was removed or damaged, cancer thrived. Over the years, researchers have discovered methods that have allowed them to experimentally remove the RB gene in order to study it, but just how the gene’s loss made cancers more aggressive was poorly understood. By studying patient samples, …

20
Nov

CyberKnife Provides Long-term Disease Control for Prostate Cancer Patients

Jefferson now offers treatment with the CyberKnife® System, a noninvasive alternative to surgery for treating cancerous and noncancerous tumors, which has been shown to provide excellent long-term results for patients with low-and intermediate-risk prostate cancer. According to a recent national 17-center study, after 10 years 98.4 percent of the 230 men monitored with low-risk prostate cancer who were treated with the …

7
Nov

Sidney Kimmel Cancer Center Grand Rounds Lecture: Elizabeth A. Platz

The Sidney Kimmel Cancer Center at Jefferson is pleased to welcome Elizabeth A. Platz, ScD, MPH, as this week’s lecturer in our Grand Rounds Series. Her talk is entitled “Population Science: Collaborating to Uncover Cancer Etiology While Reflecting on Translation to Reduce Cancer Burden.” Dr. Platz is a Professor, Martin D. Abeloff, MD Scholar in …

19
Oct

Knudsen and Kelly Receive NCI Funding

Two Sidney Kimmel Cancer Center investigators, Karen Knudsen, PhD, and Wm. Kevin Kelly, DO, have been awarded a new R01 grant from the National Cancer Institute to develop more effective therapeutic strategies for advanced prostate cancer. The project builds on previous discoveries from these investigators that identified specific cell cycle alterations in metastatic castrate-resistant prostate cancer and …

13
Oct

Ayesha Shafi receives PCF Young Investigator Award

Ayesha Shafi, PhD, a postdoctoral researcher in the laboratory of Sidney Kimmel Cancer Center Director Dr. Karen Knudsen, has been awarded a prestigious Prostate Cancer Foundation (PCF) Young Investigator Award. Shafi is conducting research on the role of the androgen receptor and the DNA repair factor DNA-dependent protein kinase in prostate cancer. Her studies are …

5
May

Getting Personal about Inherited Risk for Prostate Cancer

A new study published in JCO Precision Oncology by lead investigator Veda N. Giri, MD, at the Sidney Kimmel Cancer Center at Jefferson takes an important step in deciphering the genetic landscape contributing to inherited prostate cancer. Genetic Evaluation of Men (GEM) is a study focused on uncovering the genetic contribution to inherited prostate cancer. …

1
May

Dr. Veda Giri Featured on Congressional Directed Medical Research Programs Website

The research of Sidney Kimmel Cancer Center investigator Veda Giri, MD, has been highlighted on the Congressionally Directed Medical Research Programs (CDMRP) website. Giri and her team received funding from the U.S. Department of Defense Prostate Cancer Research Program (PCRP) to conduct studies on men at high risk for aggressive prostate cancer.  She and her …

17
Feb

Five Easy Ways to Lower Your Cancer Risk

February is National Cancer Prevention Month. Below are 5 easy ways to help reduce your risk of developing cancer, thanks to Amy Leader, PhD, and Charnita Zeigler-Johnson, PhD, both Assistant Professors in the Department of Medical Oncology.  1. Healthy diet It is well known that a poor diet can lead to being overweight or obese, which …

23
Dec

Two SKCC PhD Students Invited To Present Research At International Meetings

Congratulations to two PhD students in Dr. Karen Knudsen’s laboratory who have been invited to speak at upcoming Keystone Symposia on Molecular and Cellular Biology!! Jennifer Jones McMann, a student in the Genetics, Genomics and Cancer Biology PhD Program, will present “Novel Action of p53 Gain-of-Function Mutation in Prostate Cancer Progression” at the Keystone Conference …

14
Apr

DOD Grant Awarded To Drs. Zeigler-Johnson and Amy Leader

Charnita Zeigler-Johnson, PhD, Assistant Professor of Medical Onoclogy and Amy Leader, PhD, Assistant Professor of Medical Oncology have been awarded a DOD Synergistic Award to support a project called, “A neighborhood-based intervention to reduce prostate cancer disparities.” This grant is a 3-year award. Dr. Ziegler Johnson will be serving as s the PI, and Dr. …

14
Apr

SKCC Scientists Show That Cancer Cells Can Use Exosome Transfer To Pass On Agressive Traits

Until recently, researchers thought that cell division was the only way for an aggressive cancer cell to pass its traits along. New evidence is showing that cancers can become more dangerous by exporting aggressive traits to neighboring cells via exosomes. These small packages — bubbles — of membrane released into the extracellular environment hold pieces …

17
Feb

New genomic test can direct appropriate use of radiation therapy following prostate surgery

The identification of the right patients for post-operative radiation therapy and the timing of administering that therapy are not easily answered by clinical risk factors alone. The study, published in the Journal of Clinical Oncology, showed that patients with low genomic risk may be optimally managed with observation after radical prostatectomy (prostate surgery), while those …

17
Feb

Dr. William Kevin Kelly appointed leader of the Biology of Prostate Cancer Program

The Sidney Kimmel Cancer Center would like to congratulate Wm. Kevin Kelly, D.O., Professor of Medical Oncology and Director of the Division of Solid Tumor Oncology, on his new appointment as the Leader of the Biology of Prostate Cancer Program.  Dr. Kelly has been a considerable asset to the cancer center and Jefferson as a …

25
Dec

Dr. Carmine Fedele is awarded an AICF Fellowship

Carmine Fedele, PhD, a post-doctoral fellow in Dr. Languino’s lab, has been awarded a 2014-2015 Fellowship (2nd year) from the American Italian Cancer Foundation. His project involves determining the effect of integrin expression on the composition and function of exosomes in prostate cancer cells. For more details about the American Italian Cancer Foundation, please see …

23
Dec

Dr. Nevalainen wins SKCC Innovator of the Year Award

On December 16, 2014, Dr. Marja Nevalainen was awarded the 2014 Sidney Kimmel Cancer Center Innovator of the Year award. The award was presented presented by Dr. Richard G. Pestell, Director of the Sidney Kimmel Cancer Center.

8
Sep

Dr. Gomella, Associate Director for Clinical Affairs Appointed to NCI Genitourinary Cancers Steering Committee

Dr. Leonard Gomella, Chairman of the Department of Urology and Associate Director for Clinical Affairs for the Sidney Kimmel Cancer at Jefferson has been appointed to serve on the NCI Genitourinary Cancers Steering Committee (GUSC). The GUSC is one of sixteen steering committees formed to leverage current NCI-supported NCTN Groups, Consortia, SPOREs and Cancer Center …

27
Feb

Dr. Gomella elected to the Clinical Society of Genitourinary Surgeons

Leonard G. Gomella, MD, The Bernard W. Godwin Professor of Prostate Cancer, Chairman, Department of Urology, Associate Director, Jefferson Kimmel Cancer Center, Clinical Director Jefferson Kimmel Cancer Center Network, Editor-in-Chief, Canadian Journal of Urology has been elected to the Clinical Society of Genitourinary Surgeons. This is considered one of the most prestigious societies in the …

12
Dec

Jefferon’s Kimmel Cancer Center Holds 5th Annual Men’s Event

Jefferson’s Kimmel Cancer Center hosted its 5th Annual Men’s Event to benefit prostate cancer research and awareness at the Prime Rib Restaurant on November 14. Below are some photos of the night, award ceremony and entertainment provided by Comedy Central’s “100 Greatest Stand-Ups of All Time,” Jim Breuer of Saturday Night Live.

16
Sep

A Link between Hormones and DNA Repair Provide New Clues to Treat Advanced Prostate Cancer

For advanced prostate cancers, new strategies for therapeutic intervention are urgently needed, and require a better understanding of how tumor cells go from slow growth to aggressive behaviors that threaten patient lives. A new study, published by Thomas Jefferson University’s Kimmel Cancer Center researchers in the September 11th online edition of the journal Cancer Discovery, …

23
Aug

KCC Ranked as One of Best Cancer Hospitals in US

Men’s Health magazine recently ranked the Kimmel Cancer Center at Jefferson among the best in the nation, calling out its success in treating prostate cancer, a leading cancer in men. The American Cancer Society estimates there will be more than 1.5 million new cancer diagnoses in 2013. Jefferson scientist, Matthew Schiewer, Ph.D., recently received the Prostate Cancer Benjamin …

18
Jun

KCC Investigator wins Prostate Cancer Foundation Benjamin Franklin Young Investigator Award

Matthew Schiewer, PhD, a postdoctoral fellow in Dr. Karen Knudsen’s lab in the Department of Cancer Biology, is the recent recipient of a Prostate Cancer Foundation Young Investigator Award. Dr. Schiewer’s investigations will focus on the role of PARP-1 in DNA damage repair and the inhibition of PARP with specific medications as a potential therapy …

12
Feb

Jefferson Radiation Oncology Resident Looks to Improve Prostate Cancer Outcomes in Ghana

A new study published in January in the journal BMC Cancer, led by Kosj Yamoah, M.D., Ph.D., a resident in the Department of Radiation Oncology at Thomas Jefferson University and Hospital, takes aim at the issue by investigating prostate cancer diagnoses and treatment delivery in black men living in the West African region, in order …

21
Dec

Game changing diagnostic & prognostic prostate cancer genetic tests revealed by KCC researchers

Researchers at the Kimmel Cancer Center at Jefferson (KCC) have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers. The team, led by Richard G. Pestell, M.D., Ph.D., Director of the KCC and the Chair of the Department of Cancer Biology at Thomas Jefferson …

21
Dec

KCC researchers discover new pathways that drive metastatic prostate cancer

Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on December 21 in the Journal of Clinical Investigation by researchers at the Kimmel Cancer Center at Jefferson. The group, headed by Karen E. Knudsen, Ph.D., Professor …

16
Oct

Stat5 Predicts Outcomes for Prostate Cancer Patients after Radical Prostatectomy

Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson’s Kimmel …

9
Oct

Doubling up on Advanced Prostate Cancer with PARP Inhibitors

A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson’s Kimmel Cancer Center researchers suggests. The team, led by Karen E. Knudsen, Ph.D., Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology at …

14
Sep

Jefferson and the Eagles Team Up for Prostate Health and Cancer Awareness

September is Prostate Cancer Awareness month, and Thomas Jefferson University Hospitals has again teamed up with the Philadelphia Eagles to educate fans and others about prostate health and to raise cancer awareness. To help kick off the campaign, Jefferson will serve as the presenting partner at the Sunday, September 16 game versus the Baltimore Ravens, with …

7
Sep

Dr. Karen Knudsen Led Group Receives Million Dollar Prostate Cancer Foundation Award

A group of investigators led by Dr. Karen Knudsen was awarded a 2-year challenge grant of one million dollars by the Prostate Cancer Foundation.  The details of this award (from the PCF web site) are: 2012 Movember-PCF Challenge Award Lead Investigator: Karen Knudsen, PhD Thomas Jefferson University Title Interrogation of Aberrant DNA Repair in Sporadic …

31
May

ASCO: Liver Metastases and its Prognostic Significance in Men With Metastatic Castration-Refractory Prostate Cancer

Liver metastases predicts shorter overall survival in men with metastatic castration-refractory prostate cancer (mCRPC), according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract # 4655, Sunday, June 3, 8:00 AM – 12:00 PM CST, S Hall A2). In a phase III trial, lead study author William …

23
May

Data Continues to Support Provenge’s Overall Survival Benefit in Prostate Cancer Patients

This article was adapted from an OncLive story posted on May 21, 2012. Leonard G. Gomella, M.D, chair of the Department of Urology at Thomas Jefferson University Hospital and director of Clinical Affairs, Jefferson’s Kimmel Cancer Center, was part of the team to present new findings from the IMPACT trial looking at the immunotherapy sipuleucel-T …

16
May

Jefferson Receives $2.6 Million NIH Grant to Study Imaging Method to Stage Prostate Cancer Without Biopsy

Jefferson’s Kimmel Cancer Center and the Department of Radiology at Thomas Jefferson University received a five-year, $2.6 million grant from the National Institutes of Health (NIH) to investigate a potentially revolutionary method that can stage prostate cancers and detect recurrent disease so accurately, it would significantly reduce the number of confirmation biopsies. Such biopsies can …

29
Mar

Dr. Leonard Gomella, Program Director for IPCC in New York

Leonard G. Gomella, M.D., FACS, Chair of Urology at Thomas Jefferson University Hospital and Director of Clinical Affairs at the Kimmel Cancer Center at Jefferson, will serve as the Program Director for the Fifth Annual Interdisciplinary Prostate Cancer Congress (IPCC) at the New York Marriott East Side in New York City on March 31. This …

22
Feb

PCF Young Investigator Award Goes to Jefferson Researcher

Heather Montie, Ph.D., a post-doctoral research fellow in the Department of Biochemistry and Molecular Biology, has received a Prostate Cancer Foundation Young Investigator Award for her work with androgen receptor (AR) acetylation and its role in castration-resistant prostate cancer. Young Investigator awards are designed to promote long-term careers in the field of prostate cancer by …

13
Feb

Curry spice component may help slow prostate tumor growth

Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson’s Kimmel Cancer Center suggests. Reporting in a recent issue of Cancer Research, Karen Knudsen, Ph.D., a Professor of Cancer Biology, Urology and Radiation …

8
Feb

2011 Men’s Event Benefiting Prostate Cancer Research and patient care at Jefferson’s Kimmel Cancer Center

On Tuesday, November, 17th 2011, the Kimmel Cancer Center at Jefferson held the Third Annual Men’s Event benefiting prostate cancer research and patient care at the Prime Rib Restaurant in Philadelphia. The Men’s Event was emceed by Philadelphia Eagles Longsnapper, motivational speaker and magician, Jon Dorenbos. Receiving the Symbol of Courage was John Beuhler, prostate …

26
Jan

Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds

Brachytherapy for high-risk prostate cancers patients has historically been considered a less effective modality, but a new study from radiation oncologists at the Kimmel Cancer Center at Jefferson suggests otherwise. A population-based analysis looking at almost 13,000 cases revealed that men who received brachytherapy alone or in combination with external beam radiation therapy (EBRT) had …

16
Jan

New Clinical Trial: Cabazitaxel with Radiation and Hormone Therapy May Improve Prostate Cancer Survival

Jefferson’s Kimmel Cancer Center has started a Phase I clinical trial investigating the latest prostate cancer chemotherapy drug to extend survival, Cabazitaxel, in combination with radiation and hormone therapy. This first-of-its-kind multimodality approach could improve disease control and eventually survival for locally advanced prostate cancer patients. The single-center, open-label, non-randomized Phase I study of weekly Cabazitaxel …

14
Oct

Ulrich Rodeck receives Ben Franklin-PCF Creativity Award

Ulrich Rodeck, M.D., Ph.D., a professor in the Department of Dermatology and Cutaneous Biology, at Jefferson Medical College, Thomas Jefferson University, received the Ben Franklin-Prostate Cancer Foundation Creativity award for his work in improving the therapeutic window of radiation therapy for prostate cancer. Radiation therapy of locally advanced prostate cancer is associated with severe toxicity …

29
Sep

Kimmel Cancer Center at Jefferson Celebrates 20 Years of Patient Care and Cancer Discovery

From October forward, the Kimmel Cancer Center at Jefferson (KCC), a National Cancer Institute-designated cancer center, is celebrating 20 years of service to the community and the groundbreaking cancer research from the scientists and physicians who’ve provided an invaluable contribution to medical science and healthcare. “This is truly a milestone for the Kimmel Cancer Center—it’s …

29
Aug

Robert B. Den, M.D., Joins the Department of Radiation Oncology at Jefferson

Radiation oncologist Robert B. Den, M.D., recently joined Thomas Jefferson University Hospital as an attending physician, and was also named an assistant professor at Jefferson Medical College of Thomas Jefferson University in the Department of Radiation Oncology. Dr. Den is a clinical scientist who specializes in the treatment of prostate cancer, combining his laboratory research …

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