Category Cancer Types

1
Aug

Nicole Simone, M.D., Receives ASTRO Research Award

The American Society for Radiation Oncology (ASTRO) has awarded five physicians with research grants to promote the continued advancement of radiation therapy. One of this year’s recipient for the Junior Faculty Career Research Training Award is Nicole L. Simone, M.D., of the Department of Radiation Oncology at Thomas Jefferson University Hospital. The Junior Faculty Award …

26
Jul

Breast Cancer Patients Who Lack RB Gene Respond Better to Neoadjuvant Chemotherapy

Breast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research. Many breast cancer patients undergo neoadjuvant therapy …

14
Jun

How Aging Normal Cells Fuel Tumor Growth and Metastasis

It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of …

14
Jun

Kimmel Cancer Center at Jefferson Hosts a Patient Symposium Focusing on Melanoma of the Eye

The Kimmel Cancer Center will host the inaugural “Eyes on a Cure: Patient and Caregiver Symposium”  on June 16 and 17. The symposium will bring uveal melanoma patients, caregivers, and researchers from around the world together to offer educational sessions, support groups led by oncology social workers, sessions on complementary therapies, as well as informal …

13
Jun

HIV Drug May Slow Down Metastatic Triple-Negative Breast Cancer

Researchers at the Kimmel Cancer Center, led by Dr. Richard G. Pestell have discovered that FDA-approved HIV drugs may stop triple-negative breast cancer from spreading to other organs in pre-clinical models. These results were originally reported in Cancer Research. Recent articles about this discovery have also appeared in NewsWise and the Philadelphia Inquirer.

7
Jun

HIV drug may slow down metastatic breast cancer

The HIV drugs known as CCR5 antagonists may also help prevent aggressive breast cancers from metastasizing, researchers from the Kimmel Cancer Center at Jefferson suggest in a preclinical study published in a recent issue of Cancer Research. Such drugs target the HIV receptor CCR5, which the virus uses to enter and infect host cells, and …

31
May

ASCO: Younger Colon Cancer Patients Have Worse Prognosis at Diagnosis, Yet Better Survival

Younger patients with colorectal cancer were more likely to present advanced stage tumors at diagnosis and metastasize much sooner, yet had better than or equal survival to patients 50 and older, according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract #3621, Monday, June 4, 8:00 AM …

31
May

ASCO: Liver Metastases and its Prognostic Significance in Men With Metastatic Castration-Refractory Prostate Cancer

Liver metastases predicts shorter overall survival in men with metastatic castration-refractory prostate cancer (mCRPC), according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract # 4655, Sunday, June 3, 8:00 AM – 12:00 PM CST, S Hall A2). In a phase III trial, lead study author William …

23
May

Data Continues to Support Provenge’s Overall Survival Benefit in Prostate Cancer Patients

This article was adapted from an OncLive story posted on May 21, 2012. Leonard G. Gomella, M.D, chair of the Department of Urology at Thomas Jefferson University Hospital and director of Clinical Affairs, Jefferson’s Kimmel Cancer Center, was part of the team to present new findings from the IMPACT trial looking at the immunotherapy sipuleucel-T …

22
May

Jefferson’s Kimmel Cancer Center to Host Tribute Dinner Honoring Steve Sabol, President of NFL Films

Jefferson’s Kimmel Cancer Center will host a tribute dinner to honor legendary filmmaker Steve Sabol, President of NFL Films, with the Spirit of Courage Award at the Union League of Philadelphia on June 5. The award is presented to an individual who has demonstrated great personal courage, strength and dignity while battling cancer and supporting …

16
May

Jefferson Receives $2.6 Million NIH Grant to Study Imaging Method to Stage Prostate Cancer Without Biopsy

Jefferson’s Kimmel Cancer Center and the Department of Radiology at Thomas Jefferson University received a five-year, $2.6 million grant from the National Institutes of Health (NIH) to investigate a potentially revolutionary method that can stage prostate cancers and detect recurrent disease so accurately, it would significantly reduce the number of confirmation biopsies. Such biopsies can …

10
May

A Closer Look at PARP-1 Reveals Potential New Drug Targets

A new study published in Science May 11 is shedding light on the molecular details of PARP-1, a DNA damage-detecting enzyme that when inhibited has been shown to be effective in fighting cancer and other diseases. The investigation led by John M. Pascal, Ph.D., an assistant professor in the Department of Biochemistry and Molecular Biology …

8
May

Dr. Jeannie Hoffman-Censits leads Walk for Bladder Cancer

On Saturday, May 5, 2012 Jeannie Hoffman-Censits, M.D. led Team Jefferson from the Kimmel Cancer Center‘s Bluemle Life Sciences Building to Independence Hall. Dr. Hoffman-Censits teamed up with “the first national advocacy organization devoted to bladder cancer,” the Bladder Cancer Advocacy Network, to help raise public awareness of bladder cancer and much needed funding. Team …

7
May

Dr. Ronald Myers selected to chair Expert Working Group discussion

Ronald Myers, Ph.D., Professor of Medical Oncology and Director of the Division of Population Science at Thomas Jefferson University, has been selected to chair an Expert Working Group discussion at the World Endoscopy Organization meeting on May 18, 2012. The discussion entitled “Improving Population Engagement in Screening” is being held ahead of the DDW Conference …

26
Apr

Scott Waldman Awarded CURE Grant to Move Colon Cancer Test Closer to Commercialization

Scott Waldman, M.D., Ph.D., Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been awarded a Commonwealth Universal Research Enhancement (CURE) grant for almost $750,000 to help advance a molecular diagnostic test for colon cancer into commercialization. Such a test would better detect recurrence in a group of colon cancer …

25
Apr

You Can Help Save PA Research Funding

For more than a decade, Pennsylvania’s Commonwealth Universal Research Enhancement Program (CURE) has supported a broad range of biomedical research at 39 institutions across Pennsylvania. These funds have led to research advances in cancer, cardiovascular disease, diabetes, infectious diseases, and other health areas and improvements in public health. In his budget for fiscal year 2013, …

19
Apr

Dawn Scardino named 2012 LLS Woman of the Year

Dawn Scardino, Coordinator of Academic Services in the Department of Medical Oncology, was named the 2012 Leukemia & Lymphoma Society’s Woman of the Year for the eastern Pennsylvania Chapter. Dawn took the top recognition for raising almost $27,000 in a 10-week fundraising “race” that began on Jan. 30 and ended on April 12.  Four women …

12
Apr

Leading the Way to a Cure

It is estimated that more than 70,000 new cases of bladder cancer were diagnosed in 2011, making it the fifth most commonly diagnosed cancer in the U.S. Please join Team Jefferson and Dr. Jean Hoffman-Censits of the Department of Medical Oncology, Solid Tumor Division and the Kimmel Cancer Center at Jefferson in raising awareness of …

5
Apr

Edith Mitchell, M.D., FACP, Named 2012 Recipient of ASCO Humanitarian Award

Edith  Mitchell, M.D., FACP, a medical oncologist at Thomas Jefferson University Hospital and Jefferson’s Kimmel Cancer Center (KCC) and Clinical Professor of Medicine and Medical Oncology in the Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, has been named the 2012 recipient of the American Society of Clinical Oncology (ASCO) Humanitarian …

5
Apr

Ovarian, Glioblastoma & Non-Small Cell Lung Cancer: Jefferson Researchers Present at AACR

Several researchers from Jefferson’s Kimmel Cancer Center presented abstracts at the American Association for Cancer Research Annual Meeting 2012 in Chicago. Some of those findings include: HuR and Ovarian Cancer Silencing HuR may be a promising therapeutic approach for the treatment of ovarian cancer, according to an abstract presented at AACR by researchers from Thomas …

3
Apr

AACR: New Biomarker to Identify Hepatitis B-Infected Patients at Risk for Liver Cancer

CHICAGO— Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson’s Kimmel Cancer Center at the American Association for Cancer Research (AACR) …

3
Apr

AACR: Eliminating the ‘Good Cholesterol’ Receptor May Fight Breast Cancer

CHICAGO— Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson’s Kimmel Cancer Center researchers. In vitro and mouse studies revealed that depletion of the SR-BI resulted in a decrease in breast cancer cell …

29
Mar

Dr. Leonard Gomella, Program Director for IPCC in New York

Leonard G. Gomella, M.D., FACS, Chair of Urology at Thomas Jefferson University Hospital and Director of Clinical Affairs at the Kimmel Cancer Center at Jefferson, will serve as the Program Director for the Fifth Annual Interdisciplinary Prostate Cancer Congress (IPCC) at the New York Marriott East Side in New York City on March 31. This …

26
Mar

Jefferson Graduate Student Receives Joanna M. Nicolay Melanoma Foundation ‘Research Scholar Award’

Kevin Basile, a Thomas Jefferson University graduate student in the Genetics Ph.D. Program, was one of nine students from leading cancer centers across the U.S. to receive a $10,000 “Research Scholar Award” from the Joanna M. Nicolay Melanoma Foundation (JMNMF) for his exceptional research work. Two members of the board of directors for JMNMF, including …

20
Mar

Biomarker Links Clinical Outcome with New Model of Lethal Tumor Metabolism

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells.  Their findings were published online March 15 in Cell Cycle. To validate the prognostic value of the biomarker, …

13
Mar

Rawls Palmer Progress in Medicine Award Presented to Dr. Scott A. Waldman

Scott A. Waldman, M.D., Ph.D., will receive the American Society for Clinical Pharmacology and Therapeutics (ASCPT) Rawls–Palmer Progress in Medicine Award at the 2012 Annual Meeting on March 16. Established in 1978 by Dr. W. B. Rawls, the award recognizes scientists who have implemented progressive research techniques and tools to improve patient care. ASCPT will …

28
Feb

A New Battlefront: Symposium at Jefferson’s Kimmel Cancer Center to Tackle Geriatric Oncology

Approaches to treating elderly cancer patients are evolving as more of the population ages and the need for specialized care becomes more evident. To address these issues and others, national thought leaders in geriatric oncology will gather at a unique symposium at the Kimmel Cancer Center at Jefferson (KCC) in Philadelphia on Friday, March 9, …

22
Feb

PCF Young Investigator Award Goes to Jefferson Researcher

Heather Montie, Ph.D., a post-doctoral research fellow in the Department of Biochemistry and Molecular Biology, has received a Prostate Cancer Foundation Young Investigator Award for her work with androgen receptor (AR) acetylation and its role in castration-resistant prostate cancer. Young Investigator awards are designed to promote long-term careers in the field of prostate cancer by …

22
Feb

Dr. Renato V. Iozzo receives an honorary degree from Semmelweis University in Budapest, Hungary

Congratulations to Renato V. Iozzo, M.D., a Professor of Pathology and Cell Biology, and Professor of Biochemistry & Molecular Biology, Thomas Jefferson University, for receiving an honorary degree (Doctor Honoris Causa) from Semmelweis University in Budapest, Hungary. Dr. Iozzo received this award in November 2011 in recognition for his contributions to the field of Matrix …

21
Feb

Stronger Intestinal Barrier May Prevent Cancer in the Rest of the Body, New Study Suggests

A leaky gut may be the root of some cancers forming in the rest of the body, a new study published online Feb. 21 in PLoS ONE by Thomas Jefferson University researchers suggests. It appears that the hormone receptor guanylyl cyclase C (GC-C)—a previously identified tumor suppressor that exists in the intestinal tract—plays a key …

16
Feb

Jefferson’s Kimmel Cancer Center Establishes Center to Eliminate Cancer Disparities

PHILADELPHIA—In an effort to reduce and eventually eliminate cancer disparities among adults in the Philadelphia region, the Kimmel Cancer Center at Jefferson has established the Center to Eliminate Cancer Disparities. Edith P. Mitchell, M.D., FACP, a medical oncologist at Thomas Jefferson University Hospital and Clinical Professor of Medicine and Medical Oncology in the Department of …

15
Feb

Taxpayers Give Back for Cancer: Jefferson Researcher Awarded ‘Refunds for Research’ Grant

Takemi Tanaka, Ph.D., of Thomas Jefferson University’s School of Pharmacy and the Kimmel Cancer Center, received a $50,000 grant toward her breast cancer research, as part of the Pennsylvania Breast Cancer Coalition’s (PBCC) “Refunds for Breast and Cervical Cancer Research” initiative. The PBCC’s grants are made possible through contributions from state taxpayers who choose to …

13
Feb

Curry spice component may help slow prostate tumor growth

Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson’s Kimmel Cancer Center suggests. Reporting in a recent issue of Cancer Research, Karen Knudsen, Ph.D., a Professor of Cancer Biology, Urology and Radiation …

8
Feb

2011 Men’s Event Benefiting Prostate Cancer Research and patient care at Jefferson’s Kimmel Cancer Center

On Tuesday, November, 17th 2011, the Kimmel Cancer Center at Jefferson held the Third Annual Men’s Event benefiting prostate cancer research and patient care at the Prime Rib Restaurant in Philadelphia. The Men’s Event was emceed by Philadelphia Eagles Longsnapper, motivational speaker and magician, Jon Dorenbos. Receiving the Symbol of Courage was John Beuhler, prostate …

7
Feb

Jefferson appoints Administrator, Radiation Oncology

Thomas Jefferson University Hospital has selected Alex Khariton to become its Administrator for the Department of Radiation Oncology. Previously, Mr. Khariton had been the Administrative Director for the Department of Radiation Oncology at Cooper University Hospital in Camden, N.J., for the past eight years. “I”m looking forward to working for an  NCI-designated cancer center that …

7
Feb

Drugs targeting chromosomal instability may fight a particular breast cancer subtype

Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson’s Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of Cancer Biology, have shown in a study published online Feb. 6 in the Journal of Clinical Investigation …

27
Jan

‘A Welcome New Addition’ to Field: Dr. Juan Palazzo Authors Breast Pathology Book

Juan P. Palazzo, M.D., an anatomic/surgical pathologist at Thomas Jefferson University Hospital and the Jefferson Breast Care Center, has authored a book that tackles the hard cases in breast disease pathology faced by many clinicians in the healthcare world today. According to Amazon, Difficult Diagnoses in Breast Pathology (Demos Medical) provides a highly visual presentation …

26
Jan

Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds

Brachytherapy for high-risk prostate cancers patients has historically been considered a less effective modality, but a new study from radiation oncologists at the Kimmel Cancer Center at Jefferson suggests otherwise. A population-based analysis looking at almost 13,000 cases revealed that men who received brachytherapy alone or in combination with external beam radiation therapy (EBRT) had …

19
Jan

KCC To Host Melanoma Research Foundation Symposium

CURE OM has announced the inaugural Eyes on a Cure: Patient and Caregiver Symposium to be held on June 16th and 17th, 2012.  The meeting will be held one month after the first CURE OM Scientific Meeting (for physicians and researchers) with the goal of bringing the latest news from the ocular melanoma scientific community …

18
Jan

High Dose Vitamin C for Advanced Pancreatic Cancer

By Josh Goldstein, The Daily Dose @Jefferson A small phase I clinical trial at Jefferson University Hospitals of high-dose, intravenous vitamin C in combination with chemotherapy medications show that this treatment is safe and may have promise for patients with advanced pancreatic cancer. The study published in the open access online journal PLoS ONE tested …

16
Jan

New Clinical Trial: Cabazitaxel with Radiation and Hormone Therapy May Improve Prostate Cancer Survival

Jefferson’s Kimmel Cancer Center has started a Phase I clinical trial investigating the latest prostate cancer chemotherapy drug to extend survival, Cabazitaxel, in combination with radiation and hormone therapy. This first-of-its-kind multimodality approach could improve disease control and eventually survival for locally advanced prostate cancer patients. The single-center, open-label, non-randomized Phase I study of weekly Cabazitaxel …

12
Jan

KCC’s Brain Tumor Center’s New Immunotherapy Clinical Trial Featured in Several News Outlets

Led by Dr. David Andrews, co-director of the Brain Tumor Center of the Kimmel Cancer Center, a new immunotherapy clinical trial at Jefferson will harvest cells from brain tumors for use in treatment. In an interview with KYW Newsradio, Dr. Andrews explains that the first step of the trial will be a surgical procedure to take cells from the brain tumor. He …

12
Jan

Dr. Gomella Talks To 6 ABC About New Light Cystscopy To Better Detect Bladder Cancer

Each year, approximately 70,000 Americans are diagnosed with bladder cancer. In the past, detecting tumors on the bladder wall has been a challenge but a new procedure at Jefferson, blue light cystoscopy, allows doctors to better see where the tumors are located. In an interview with 6 ABC, Dr. Leonard Gomella, chair of Jefferson’s Department …

15
Dec

Richard Pestell Named AAAS Fellow

Richard Pestell, M.D., Ph.D., FACP, Director of the Kimmel Cancer Center at Jefferson (KCC), has been named a 2011 Fellow of the American Association for the Advancement of Science (AAAS). As part of the Section on Medical Sciences, Dr. Pestell was elected as an AAAS Fellow for his distinguished contributions to cancer care as director …

15
Dec

Russell J. Schilder, M.D., Joins Jefferson as Director of Gynecologic Medical Oncology

PHILADELPHIA—Russell J. Schilder, M.D., recently joined Thomas Jefferson University Hospital as Director of the Gynecologic Medical Oncology Program at the Kimmel Cancer Center at Jefferson. Prior to his arrival at Jefferson, Dr. Schilder served as a professor in the Department of Medical Oncology and Chief of Gynecologic Medical Oncology at Fox Chase Cancer Center. “It’s …

13
Dec

Loss of RB in Triple Negative Breast Cancer Associated with Favorable Clinical Outcome

Researchers at the Thomas Jefferson University Hospital and Kimmel Cancer Center at Jefferson have shown that loss of the retinoblastoma tumor suppressor gene (RB) in triple negative breast cancer patients is associated with better clinical outcomes. This is a new marker to identify the subset of these patients who may respond positively to chemotherapy. Today, …

12
Dec

Dr. Bo Lu to Lead the Radiation Therapy Oncology Group’s Lung Cancer Translational Research Program

The Radiation Therapy Oncology Group (RTOG) announced that Bo Lu, M.D., Ph.D., of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson, has been appointed chair of the group’s Translational Research Program (TRP) Committee’s Lung Cancer Subcommittee. The RTOG TRP Committee supports the integration of new scientific discoveries into the design of multi-center clinical …

9
Dec

New “Achilles’ Heel” in Breast Cancer: Tumor Cell Mitochondria

Researchers at the Kimmel Cancer Center at Jefferson have identified cancer cell mitochondria as the unsuspecting powerhouse and “Achilles’ heel” of tumor growth, opening up the door for new therapeutic targets in breast cancer and other tumor types. Reporting in the online Dec.1 issue of Cell Cycle, Michael P. Lisanti, M.D., Ph.D., Professor and Chair …

5
Dec

KCC’s 3rd Annual Men’s Event

Another successful year! The Kimmel Cancer Center hosted its 3rd annual Men’s Event at the Prime Rib in Philadelphia on November 15. About 150 people joined Richard Pestell, M.D., Ph.D., Director, Kimmel Cancer Center at Jefferson, Leonard Gomella, M.D., Chair, Department of Urology at Jefferson and 2011 Men’s Event Co-Chairs Edward Glickman, President of Pennsylvania …

8
Nov

Kimmel Cancer Center Hosts Interurban Clinical Club

On Friday, October 28, the Kimmel Cancer Center at Jefferson hosted the 204th meeting of the Interurban Clinical Club at Jefferson Medical College of Thomas Jefferson University. The Interurban Clinical Club is a prestigious club founded by Sir William Osler in 1905 for the purpose of exchanging ideas and fellowship among medical teachers in some …

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