Category Cancer Types

5
Apr

SKCC Team Sticks a DNA Replication Fork into Lymphoma Development

A new study from Sidney Kimmel Cancer Center – Jefferson Health (SKCC) researchers provides important insights into the role of DNA replication fork remodeling in mitigating stress on DNA caused by dysregulation of the Myc oncogene, which occurs in at least 70 percent of human cancers. The study was published in the journal Cancer Research. …

27
Mar

Eyes on the Prize: Developing Better Treatments for Uveal Melanoma

Uveal melanoma arises in the eye, in contrast to the more widely known skin melanoma, and it often spreads to the liver, where it becomes highly resistant to treatment. Researchers from the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) in Philadelphia and Columbia University in New York have teamed up to investigate the efficacy …

19
Mar

Colon Cancer: Fact or Fiction?

By Marianne T. Ritchie, MD, Director of Sidney Kimmel Cancer Center Colon Cancer Screening/Outreach, Director of PINK PLUS Women’s Cancer Screenings Program, and Clinical Associate Professor of Gastroenterology and Hepatology. Can you tell fact from fiction when it comes to colon cancer? Learn the truth behind common myths during Colorectal Cancer Awareness Month. 1. Colon …

13
Mar

Dr. Adam Dicker Named ASCO Fellow

Adam P. Dicker, MD, PhD, has been named a Fellow of the American Society of Clinical Oncology (FASCO) in honor of his extraordinary volunteer service, dedication, and commitment to ASCO. Dicker is Senior Vice President and Chair of Enterprise Radiation Oncology; Director of the Jefferson Institute for Digital Health; and Professor of Radiation Oncology and …

28
Feb

Prostate Cancer Patients With Cardiovascular Disease Had Higher Mortality After Starting Abiraterone Acetate

Patients with advanced prostate cancer who had pre-existing cardiovascular disease had higher risk of mortality in the six months after starting abiraterone acetate (Zytiga) treatment compared with those who had no pre-existing cardiovascular disease, according to data presented during a media preview of the American Association for Cancer Research (AACR) Annual Meeting 2019, which will be …

28
Jan

Dr. Elda Grabocka Awarded Margaret Q. Landenberger Research Foundation Grant

Elda Grabocka, PhD, Assistant Professor in the Departments of Cancer Biology and Surgery at the Sidney Kimmel Cancer Center – Jefferson Health, has been awarded a grant from the Margaret Q. Landenberger Research Foundation to study KRAS-driven cancers. Her grant is titled “’Role of stress granules in the evolution of KRAS-driven tumors.” Grabocka’s research demonstrated for …

2
Jan

Dr. Veronica Rodriguez-Bravo Receives Grant from W.W. Smith Charitable Trust

Veronica Rodriguez-Bravo, PhD, Assistant Professor of Cancer Biology at Thomas Jefferson University and a member of the Sidney Kimmel Cancer Center – Jefferson Health, has been awarded a $135,000 grant for the project titled “Dissecting Targetable DNA Integrity Checkpoints in Prostate Cancer” from the W.W. Smith Charitable Trust. Rodriguez-Bravo is focused on advanced prostate cancer …

20
Dec

New Advances in Lung Cancer Research: SMACing Down Tumor Progression

An investigational class of drugs in combination with radiation therapy may improve immune function in patients. Novel advances in the treatment of lung cancer have emerged from a new preclinical study from researchers at the Sidney Kimmel Cancer Center – Jefferson Health (SKCC), published in the journal Clinical Cancer Research. The study, led by Bo …

17
Dec

New Insights Regarding Genetic Contribution to Inherited Prostate Cancer

Newly published research from Sidney Kimmel Cancer Center – Jefferson Health (SKCC) investigators provides a snapshot of the spectrum of genetic changes that are responsible for inherited prostate cancer, supporting current guidelines for genetic testing of patients with prostate cancer, as well as suggesting expanded testing to encompass additional patients. Previous studies on this topic …

21
Nov

Is CyberKnife Right for Me? Five Questions about CyberKnife Treatment for Prostate Cancer with Dr. Eric Gressen

In November, the moustache is king. Movember is a month-long initiative to bring awareness to men’s health issues, particularly prostate cancer. In the spirit of Movember, we asked Eric Gressen, MD, some common questions from patients about CyberKnife treatment for prostate cancer. Dr. Gressen is a clinical professor and a Jefferson Health physician in the …

20
Nov

Dr. Grace Lu-Yao Recognized with International Society of Geriatric Oncology Investigator Award

Grace Lu-Yao, PhD, Associate Director of Population Science at the Sidney Kimmel Cancer Center – Jefferson Health (SKCC), has been honored with the International Society of Geriatric Oncology (SIOG) 2018 Nursing and Allied Health (NAH) Investigator Award at the SIOG 2018 Annual Conference. This award recognizes significant contributions from new investigators in geriatric oncology nursing …

6
Nov

Skin Cancer Specialist Dr. Melissa Wilson Joins Sidney Kimmel Cancer Center

The Sidney Kimmel Cancer Center – Jefferson Health (SKCC) welcomes Melissa A. Wilson, MD, PhD, as a new Associate Professor of Medical Oncology. Dr. Wilson treats patients with skin cancers including melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. In addition to her clinical practice, Dr. Wilson leads clinical and translational research …

11
Oct

SKCC Researchers Receive NIH Grant to Study Prostate Cancer Disparities among African Americans

Sidney Kimmel Cancer Center – Jefferson Health (SKCC) researchers have received a planning grant for Specialized Program of Research Excellence (SPORE) to Investigate Cancer Health Disparities (P20 grant) from the National Institutes of Health (NIH) to study a “precision interception approach” to prevent prostate cancer progression among African American men. Grace Lu-Yao, PhD, MPH, Associate …

13
Sep

Sidney Kimmel Cancer Center Enhances Population Science Research with TIPS

Over the last few years, the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) has successfully integrated population science — a field of research focused on improving public health on a broad scale — into its existing five cancer research programs through the creation of a mechanism known as TIPS, short for Transdisciplinary Integration of …

16
Aug

Dr. Ana María López to Lead Medical Oncology at SKCC Jefferson Health – Washington Township

Ana María López, MD, MPH, joins the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) as the Vice Chair of Medical Oncology and Chief of Cancer Services at the Sidney Kimmel Cancer Center – Washington Township. Dr. López comes from the Huntsman Cancer Institute in Salt Lake City, where she was Director of Cancer Health …

14
Aug

SKCC Director Dr. Karen Knudsen Named Association of American Cancer Institutes’ President-Elect

Karen E. Knudsen, PhD, Enterprise Director of the National Cancer Institute (NCI)-designated Sidney Kimmel Cancer Center– Jefferson Health (SKCC), has been elected vice president/president-elect of the Association of American Cancer Institutes’ (AACI) board of directors. Dr. Knudsen, who has been serving as SKCC enterprise director since 2015, governs cancer research and cancer care across 14 hospitals within …

3
Aug

Newlyweds Face Cancer Diagnosis Together

When newly married couple Lydia and Anikait Sharma moved to the United States in 2016, they were excited about their lives in a brand new country. The London, United Kingdom natives had recently moved across the ocean to Philadelphia for Anikait’s new job as a Director of Financial Planning and Analysis. Lydia took her time …

25
Jul

Sidney Kimmel Cancer Center Announces ACS Institutional Research Grant Recipients

The Sidney Kimmel Cancer Center – Jefferson Health is pleased to announce the most recent recipients of the American Cancer Society Institutional Research Grants. American Cancer Society Institutional Research Grants are awarded to institutions as block grants to provide seed money for newly independent investigators to initiate research projects. The intent of this support is …

2
Jul

SKCC Investigators Explore New Approaches to Treating Metastatic Colorectal Cancer

A new clinical trial conducted by investigators at the Sidney Kimmel Cancer Center – Jefferson Health (SKCC) and the Lombardi Comprehensive Cancer Center at Georgetown University has generated promising results regarding a novel treatment for metastatic colorectal cancer. The new study, published in the journal Cancer, was led by Jonathan R. Brody, PhD, director of Surgical Research …

25
Jun

From Patient to Supporter: Helping Others Navigate a Cancer Diagnosis

As an Air Force and commercial airline pilot, Pete Lonngren’s top priority had always been safety. So in 2007 when he discovered a swollen lymph node in his neck, he knew he had to follow his instincts and take action for the sake of his health. Lonngren, an Indiana native who has lived in South …

13
Jun

Christine Eischen, PhD, Receives Prestigious Professorship in Cancer Research

Congratulations to Christine M. Eischen, PhD, who was recently invested as the Herbert A. Rosenthal, MD ’56 Professor in Cancer Research. Eischen is a professor and Vice Chair in the Department of Cancer Biology at Thomas Jefferson University and co-leader of the Molecular Biology & Genetics Program at the Sidney Kimmel Cancer Center at Jefferson …

24
May

Unique Clinical Trial for Melanoma Patients Begins at Sidney Kimmel Cancer Center

The first patient at the Sidney Kimmel Cancer Center at Jefferson Health recently began receiving treatment as part of a phase II clinical trial studying adjuvant nivolumab. It is a single arm study of nivolumab every 4 weeks for 12 cycles in patients with stage 2b/2c melanoma who have had their melanoma removed and a negative …

22
May

Understanding Genetic Test Results for Prostate Cancer: Needs for Men Identified

Some prostate cancer patients will need help understanding the complexity of genetic results, a new study finds. As genetic testing for various diseases gains in popularity, researchers are finding that there can be confusion about what the test results really mean, how much they increase a person’s risk of disease, and whether there’s any important …

7
May

Eye Cancer Cases in North Carolina and Alabama Baffle Physicians

The Sidney Kimmel Cancer Center at Jefferson Health (SKCC)’s renowned uveal, or ocular, melanoma program sees patients from across the country and around the world. SKCC medical oncologists who specialize in uveal melanoma work closely with a team from nearby Wills Eye Hospital to treat patients with primary ocular tumors, as well as those whose …

2
May

SKCC Researchers Receive Melanoma Research Alliance Team Science Award

Andrew Aplin, PhD, Associate Director of Basic Research and Program Leader of Cancer Cell Biology & Signaling at the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health, Kalbach-Newton Professor in Cancer Research at Thomas Jefferson University, and Department of Ophthalmology at Wills Eye Institute, and Marlana Orloff, MD, Assistant Professor of Medical Oncology at Thomas …

20
Mar

Wm. Kevin Kelly, DO, Elected as Co-Chair of NCI Steering Committee

Wm. Kevin Kelly, DO, leader of the Prostate Cancer Program and associate director of Clinical Research at the Sidney Kimmel Cancer Center at Jefferson Health (SKCC), has been elected to serve as medical oncology co-chair on the National Cancer Institute (NCI) Genitourinary Cancers Steering Committee (GUSC). The GUSC addresses the design, prioritization, and evaluation of …

12
Mar

Dan Silver, MD, PhD, Receives “Outstanding Member” Award at Cancer Center Retreat

Congratulations to Dan Silver, MD, PhD, Associate Professor of Medical Oncology and Director of Basic Science and Research in Medical Oncology, for receiving the “Director’s Award – Outstanding Member” at the recent Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. Silver, who is also the leader of …

6
Mar

Kevin Kelly, DO, Receives “Director’s Award for Impact” at Member Retreat

Congratulations to Wm. Kevin Kelly, DO, Professor of Medical Oncology and Director of the Division of Solid Tumor Oncology, for receiving the “Director’s Award for Impact” at the recent Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. Kelly, who is also the leader of the Prostate Cancer …

27
Feb

Jeff Benovic, PhD, Receives Discovery of the Year Award for Basic Science

Congratulations to Jeff Benovic, PhD, Thomas Eakins Endowed Professor of Biochemistry & Molecular Biology at Thomas Jefferson University, who was recently honored with the “Discovery of the Year Award for Basic Science” at the 2018 Sidney Kimmel Cancer Center at Jefferson Health (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. The award was presented …

9
Feb

Adam Berger, MD, FACS, Receives Sidney Kimmel Cancer Center Achievement in Clinical Research Award

Congratulations to Adam Berger, MD, FACS, Vice Chair for Clinical Research, who recently received the “Achievement in Clinical Research Award” at the 2018 Sidney Kimmel Cancer Center (SKCC) Member Retreat, held at Citizens Bank Park in Philadelphia. The award was presented to Berger by Kevin Kelly, DO, Associate Director of Clinical Research and Leader of the Prostate …

31
Jan

Veda Giri, MD, Receives Sidney Kimmel Cancer Center Population Science Award

Congratulations to Veda Nargund Giri, MD, who recently received the “Discovery of the Year Award for Population Science” at the 2018 Sidney Kimmel Cancer Center Member Retreat, held at Citizens Bank Park in Philadelphia. Giri has had long-standing interest in developing the field of genetic counseling and testing for inherited prostate cancer. She is a medical …

5
Jan

Andrew Aplin Named First Recipient of Kalbach-Newton Professorship in Cancer Research

The Sidney Kimmel Medical College (SKMC) at Thomas Jefferson University (TJU) has established a new professorship, made possible through generous donations from the estates of Raymond B. Kalbach and Caroline Newton. Mark Tykocinski, MD, Provost of TJU, and Anthony F. and Gertrude M. DePalma Dean of SKMC, has named Andrew E. Aplin, PhD, one of …

14
Dec

New Recommendations Provide Guidance on Genetic Counseling & Testing for Hereditary Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. Now, an international and interspecialty panel of experts convened at the Sidney Kimmel Cancer Center (SKCC) at Jefferson have developed a comprehensive set of recommendations. This consensus statement, published December 13th in the Journal …

13
Dec

Scott Waldman Named a 2017 Fellow of the National Academy of Inventors

Scott A. Waldman, MD, PhD, Co-Leader of the Gastrointestinal Cancer Program at the Sidney Kimmel Cancer Center at Jefferson and Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been named a Fellow of the National Academy of Inventors (NAI). Waldman is a leader in clinical pharmacology, whose groundbreaking research …

11
Dec

Sidney Kimmel Cancer Center Researchers Receive $1.3 Million from Falk Trust

How can doctors use immunotherapy to develop more effective and durable anticancer therapies? Is it possible to return aggressive cancer cells to a dormant form once they have spread? Those are two questions SKCC researchers Andrew Aplin, PhD, and Emad Alnemri, PhD, will explore with $1.3 million in grants from the Dr. Ralph and Marian …

5
Dec

Researchers Find Breakthroughs in Understanding Genetic Basis of Aggressive Prostate Cancer

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer. When it was removed or damaged, cancer thrived. Over the years, researchers have discovered methods that have allowed them to experimentally remove the RB gene in order to study it, but just how the gene’s loss made cancers more aggressive was poorly understood. By studying patient samples, …

28
Nov

Decoding the Molecular Mechanisms of Ovarian Cancer Progression

A new study from Sidney Kimmel Cancer Center (SKCC) investigator Christine Eischen, PhD, provided important new insights into the mechanisms contributing to ovarian cancer. The findings were recently published in Nature Communications. Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 …

21
Nov

Cancer Cell Signaling: Selecting the Best Importin for the Job

New research from Sidney Kimmel Cancer Center at Jefferson member Gino Cingolani, PhD, recently provided critical insights into the nuclear import of key signaling proteins, including those involved in tumorigenesis. For a vast array of cellular processes, numerous proteins must be imported and exported from the cell nucleus in a tightly regulated fashion. Typically, proteins that …

20
Nov

CyberKnife Provides Long-term Disease Control for Prostate Cancer Patients

Jefferson now offers treatment with the CyberKnife® System, a noninvasive alternative to surgery for treating cancerous and noncancerous tumors, which has been shown to provide excellent long-term results for patients with low-and intermediate-risk prostate cancer. According to a recent national 17-center study, after 10 years 98.4 percent of the 230 men monitored with low-risk prostate cancer who were treated with the …

7
Nov

Sidney Kimmel Cancer Center Grand Rounds Lecture: Elizabeth A. Platz

The Sidney Kimmel Cancer Center at Jefferson is pleased to welcome Elizabeth A. Platz, ScD, MPH, as this week’s lecturer in our Grand Rounds Series. Her talk is entitled “Population Science: Collaborating to Uncover Cancer Etiology While Reflecting on Translation to Reduce Cancer Burden.” Dr. Platz is a Professor, Martin D. Abeloff, MD Scholar in …

19
Oct

Knudsen and Kelly Receive NCI Funding

Two Sidney Kimmel Cancer Center investigators, Karen Knudsen, PhD, and Wm. Kevin Kelly, DO, have been awarded a new R01 grant from the National Cancer Institute to develop more effective therapeutic strategies for advanced prostate cancer. The project builds on previous discoveries from these investigators that identified specific cell cycle alterations in metastatic castrate-resistant prostate cancer and …

13
Oct

Ayesha Shafi receives PCF Young Investigator Award

Ayesha Shafi, PhD, a postdoctoral researcher in the laboratory of Sidney Kimmel Cancer Center Director Dr. Karen Knudsen, has been awarded a prestigious Prostate Cancer Foundation (PCF) Young Investigator Award. Shafi is conducting research on the role of the androgen receptor and the DNA repair factor DNA-dependent protein kinase in prostate cancer. Her studies are …

13
Oct

Elda Grabocka Recipient of V Foundation Scholar Research Award

Congratulations to Elda Grabocka, PhD, who has been given a prestigious V Foundation Scholar Research Award. Her grant, entitled “Targeting Stress Adaptive Mechanisms as a Strategy for Precision Oncology in Pancreatic Cancer,” is focused on investigating stress granules as predictors of drug resistance and as effective therapeutic targets for the treatment of KRAS-driven pancreatic cancer. …

19
Sep

Molecular Profiling of Key Survival Proteins in B-cell Lymphoma Subtypes

Investigators at the Sidney Kimmel Cancer Center at Jefferson uncovered potential new culprits that contribute to the development and progression of several types of lymphoma. The study was published in a recent issue of Clinical Cancer Research, with co-first authors Drs. Clare M. Adams and Ramkrishna Mitra, along with co-author Dr. Jerald Z. Gong and senior author Christine …

18
Aug

Colorectal Cancer Metastasis: A Game of Clones

Colorectal cancer is highly prevalent worldwide, and metastasis of colorectal cancer to distant sites accounts for ~90% of the mortality associated with this disease. Researchers at the Sidney Kimmel Cancer Center at Jefferson (SKCC), along with collaborators at several other institutions, tracked genomic changes that occur as colorectal tumors progress and metastasize to distant sites …

10
Aug

Cancer Immunotherapy Might Come with a Hidden Cost

Recent findings from investigators at the Sidney Kimmel Cancer Center at Jefferson raise potential concerns regarding adverse effects associated with a therapeutic approach that has revolutionized the field of cancer treatment — cancer immunotherapy. The findings were recently published in the International Journal of Radiation Oncology + Biology + Physics. In immunotherapy, clinicians harness the power of …

4
Aug

Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer

New research from investigators at the Sidney Kimmel Cancer Center at Jefferson provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. The study was recently published online in Cancer Research. The research team studied the role of an RNA-binding protein termed HuR in influencing the …

2
Aug

Abington – Jefferson Health Recognized by NRG Oncology

Congratulations to Abington – Jefferson Health, who was recently announced as the #3 top accruing Main Member site for Fiscal Year 2017 by NRG Oncology. The announcement was made at the NRG Oncology Semiannual Meeting, held July 13-15, 2017 in Philadelphia. NRG Oncology seeks to improve the lives of patients with cancer by conducting practice-changing …

26
Jul

Single-Cell Resolution Mutational Profiling in Breast Cancer

A new study from Sidney Kimmel Cancer Center at Jefferson demonstrated the feasibility of detecting cancer-associated gene mutations in circulating tumor cells (CTC) isolated from patients — providing a powerful new tool for clinicians and cancer researchers. Published in Clinical Cancer Research, the project was led by senior authors Paolo M. Fortina, MD, PhD, and Massimo …

14
Jul

A Lifelong Dedication to Cancer

When Alison Petok was five years old, her Nana died of leukemia. “If she had been diagnosed a decade or two later, perhaps she would have survived due to the advances in blood cancer research,” Alison reflected. Years later in 2017, Alison was nominated as “Woman of the Year” by The Leukemia & Lymphoma Society …

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