14
Dec

New Recommendations Provide Guidance on Genetic Counseling & Testing for Hereditary Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. Now, an international and interspecialty panel of experts convened at the Sidney Kimmel Cancer Center (SKCC) at Jefferson have developed a comprehensive set of recommendations. This consensus statement, published December 13th in the Journal …

13
Dec

Scott Waldman Named a 2017 Fellow of the National Academy of Inventors

Scott A. Waldman, MD, PhD, Co-Leader of the Gastrointestinal Cancer Program at the Sidney Kimmel Cancer Center at Jefferson and Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been named a Fellow of the National Academy of Inventors (NAI). Waldman is a leader in clinical pharmacology, whose groundbreaking research …

11
Dec

Sidney Kimmel Cancer Center Researchers Receive $1.3 Million from Falk Trust

How can doctors use immunotherapy to develop more effective and durable anticancer therapies? Is it possible to return aggressive cancer cells to a dormant form once they have spread? Those are two questions SKCC researchers Andrew Aplin, PhD, and Emad Alnemri, PhD, will explore with $1.3 million in grants from the Dr. Ralph and Marian …

5
Dec

Researchers Find Breakthroughs in Understanding Genetic Basis of Aggressive Prostate Cancer

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer. When it was removed or damaged, cancer thrived. Over the years, researchers have discovered methods that have allowed them to experimentally remove the RB gene in order to study it, but just how the gene’s loss made cancers more aggressive was poorly understood. By studying patient samples, …

28
Nov

Decoding the Molecular Mechanisms of Ovarian Cancer Progression

A new study from Sidney Kimmel Cancer Center (SKCC) investigator Christine Eischen, PhD, provided important new insights into the mechanisms contributing to ovarian cancer. The findings were recently published in Nature Communications. Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 …

21
Nov

Cancer Cell Signaling: Selecting the Best Importin for the Job

New research from Sidney Kimmel Cancer Center at Jefferson member Gino Cingolani, PhD, recently provided critical insights into the nuclear import of key signaling proteins, including those involved in tumorigenesis. For a vast array of cellular processes, numerous proteins must be imported and exported from the cell nucleus in a tightly regulated fashion. Typically, proteins that …

17
Nov

Christine Eischen Receives AACR-Bayer Innovation and Discovery Grant

Christine M. Eischen, PhD, Co-Leader of the Molecular Biology & Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has been awarded a 2017 AACR-Bayer Innovation and Discovery Grant. Her grant is entitled, “Using PROTACS to target the Mdm2 oncoprotein.” The Innovation and Discovery Grant offers one-year grants to “meritorious projects that examine important, and …

7
Nov

Sidney Kimmel Cancer Center Grand Rounds Lecture: Elizabeth A. Platz

The Sidney Kimmel Cancer Center at Jefferson is pleased to welcome Elizabeth A. Platz, ScD, MPH, as this week’s lecturer in our Grand Rounds Series. Her talk is entitled “Population Science: Collaborating to Uncover Cancer Etiology While Reflecting on Translation to Reduce Cancer Burden.” Dr. Platz is a Professor, Martin D. Abeloff, MD Scholar in …

19
Oct

Knudsen and Kelly Receive NCI Funding

Two Sidney Kimmel Cancer Center investigators, Karen Knudsen, PhD, and Wm. Kevin Kelly, DO, have been awarded a new R01 grant from the National Cancer Institute to develop more effective therapeutic strategies for advanced prostate cancer. The project builds on previous discoveries from these investigators that identified specific cell cycle alterations in metastatic castrate-resistant prostate cancer and …

13
Oct

Elda Grabocka Recipient of V Foundation Scholar Research Award

Congratulations to Elda Grabocka, PhD, who has been given a prestigious V Foundation Scholar Research Award. Her grant, entitled “Targeting Stress Adaptive Mechanisms as a Strategy for Precision Oncology in Pancreatic Cancer,” is focused on investigating stress granules as predictors of drug resistance and as effective therapeutic targets for the treatment of KRAS-driven pancreatic cancer. …

19
Sep

Molecular Profiling of Key Survival Proteins in B-cell Lymphoma Subtypes

Investigators at the Sidney Kimmel Cancer Center at Jefferson uncovered potential new culprits that contribute to the development and progression of several types of lymphoma. The study was published in a recent issue of Clinical Cancer Research, with co-first authors Drs. Clare M. Adams and Ramkrishna Mitra, along with co-author Dr. Jerald Z. Gong and senior author Christine …

18
Aug

Colorectal Cancer Metastasis: A Game of Clones

Colorectal cancer is highly prevalent worldwide, and metastasis of colorectal cancer to distant sites accounts for ~90% of the mortality associated with this disease. Researchers at the Sidney Kimmel Cancer Center at Jefferson (SKCC), along with collaborators at several other institutions, tracked genomic changes that occur as colorectal tumors progress and metastasize to distant sites …

10
Aug

Cancer Immunotherapy Might Come with a Hidden Cost

Recent findings from investigators at the Sidney Kimmel Cancer Center at Jefferson raise potential concerns regarding adverse effects associated with a therapeutic approach that has revolutionized the field of cancer treatment — cancer immunotherapy. The findings were recently published in the International Journal of Radiation Oncology + Biology + Physics. In immunotherapy, clinicians harness the power of …

4
Aug

Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer

New research from investigators at the Sidney Kimmel Cancer Center at Jefferson provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. The study was recently published online in Cancer Research. The research team studied the role of an RNA-binding protein termed HuR in influencing the …

26
Jul

Single-Cell Resolution Mutational Profiling in Breast Cancer

A new study from Sidney Kimmel Cancer Center at Jefferson demonstrated the feasibility of detecting cancer-associated gene mutations in circulating tumor cells (CTC) isolated from patients — providing a powerful new tool for clinicians and cancer researchers. Published in Clinical Cancer Research, the project was led by senior authors Paolo M. Fortina, MD, PhD, and Massimo …

11
Jul

Understanding Chemotherapy Resistance in Pancreatic Cancer

A collaborative study involving Sidney Kimmel Cancer Center at Jefferson (SKCC) investigators, together with colleagues from the University of California at San Diego, has provided important insights into how pancreatic cancer cells are able to resist the effects of chemotherapeutic agents. The new study, published in Cancer Research, was led by senior author Jordan Winter, MD, FACS, Associate Professor of …

23
Jun

Important New Insights into Key Regulatory Pathway for Cancer Cell Survival

New research from the laboratory of Christine Eischen, PhD, Co-Leader of the Molecular Biology and Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has revealed a previously unappreciated feature of a well-known cell survival mechanism with potentially important implications for the treatment of some cancers. The study, recently published in Cancer Research, focuses on the …

5
May

Getting Personal about Inherited Risk for Prostate Cancer

A new study published in JCO Precision Oncology by lead investigator Veda N. Giri, MD, at the Sidney Kimmel Cancer Center at Jefferson takes an important step in deciphering the genetic landscape contributing to inherited prostate cancer. Genetic Evaluation of Men (GEM) is a study focused on uncovering the genetic contribution to inherited prostate cancer. …

1
May

Dr. Veda Giri Featured on Congressional Directed Medical Research Programs Website

The research of Sidney Kimmel Cancer Center investigator Veda Giri, MD, has been highlighted on the Congressionally Directed Medical Research Programs (CDMRP) website. Giri and her team received funding from the U.S. Department of Defense Prostate Cancer Research Program (PCRP) to conduct studies on men at high risk for aggressive prostate cancer.  She and her …

28
Apr

Opening Up Chromatin for Cell Differentiation

Two new studies from the laboratory of Alex Mazo, PhD, at the Sidney Kimmel Cancer Center, along with collaborators from SKCC, the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University, and other institutions, provide new insights into the structure of chromatin and its implications for cellular differentiation.  The new work, appearing in …

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