Category Research

19
Sep

Molecular Profiling of Key Survival Proteins in B-cell Lymphoma Subtypes

Investigators at the Sidney Kimmel Cancer Center at Jefferson uncovered potential new culprits that contribute to the development and progression of several types of lymphoma. The study was published in a recent issue of Clinical Cancer Research, with co-first authors Drs. Clare M. Adams and Ramkrishna Mitra, along with co-author Dr. Jerald Z. Gong and senior author Christine …

18
Aug

Colorectal Cancer Metastasis: A Game of Clones

Colorectal cancer is highly prevalent worldwide, and metastasis of colorectal cancer to distant sites accounts for ~90% of the mortality associated with this disease. Researchers at the Sidney Kimmel Cancer Center at Jefferson (SKCC), along with collaborators at several other institutions, tracked genomic changes that occur as colorectal tumors progress and metastasize to distant sites …

10
Aug

Cancer Immunotherapy Might Come with a Hidden Cost

Recent findings from investigators at the Sidney Kimmel Cancer Center at Jefferson raise potential concerns regarding adverse effects associated with a therapeutic approach that has revolutionized the field of cancer treatment — cancer immunotherapy. The findings were recently published in the International Journal of Radiation Oncology + Biology + Physics. In immunotherapy, clinicians harness the power of …

4
Aug

Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer

New research from investigators at the Sidney Kimmel Cancer Center at Jefferson provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. The study was recently published online in Cancer Research. The research team studied the role of an RNA-binding protein termed HuR in influencing the …

26
Jul

Single-Cell Resolution Mutational Profiling in Breast Cancer

A new study from Sidney Kimmel Cancer Center at Jefferson demonstrated the feasibility of detecting cancer-associated gene mutations in circulating tumor cells (CTC) isolated from patients — providing a powerful new tool for clinicians and cancer researchers. Published in Clinical Cancer Research, the project was led by senior authors Paolo M. Fortina, MD, PhD, and Massimo …

11
Jul

Understanding Chemotherapy Resistance in Pancreatic Cancer

A collaborative study involving Sidney Kimmel Cancer Center at Jefferson (SKCC) investigators, together with colleagues from the University of California at San Diego, has provided important insights into how pancreatic cancer cells are able to resist the effects of chemotherapeutic agents. The new study, published in Cancer Research, was led by senior author Jordan Winter, MD, FACS, Associate Professor of …

23
Jun

Important New Insights into Key Regulatory Pathway for Cancer Cell Survival

New research from the laboratory of Christine Eischen, PhD, Co-Leader of the Molecular Biology and Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has revealed a previously unappreciated feature of a well-known cell survival mechanism with potentially important implications for the treatment of some cancers. The study, recently published in Cancer Research, focuses on the …

5
May

Getting Personal about Inherited Risk for Prostate Cancer

A new study published in JCO Precision Oncology by lead investigator Veda N. Giri, MD, at the Sidney Kimmel Cancer Center at Jefferson takes an important step in deciphering the genetic landscape contributing to inherited prostate cancer. Genetic Evaluation of Men (GEM) is a study focused on uncovering the genetic contribution to inherited prostate cancer. …

1
May

Dr. Veda Giri Featured on Congressional Directed Medical Research Programs Website

The research of Sidney Kimmel Cancer Center investigator Veda Giri, MD, has been highlighted on the Congressionally Directed Medical Research Programs (CDMRP) website. Giri and her team received funding from the U.S. Department of Defense Prostate Cancer Research Program (PCRP) to conduct studies on men at high risk for aggressive prostate cancer.  She and her …

28
Apr

Opening Up Chromatin for Cell Differentiation

Two new studies from the laboratory of Alex Mazo, PhD, at the Sidney Kimmel Cancer Center, along with collaborators from SKCC, the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University, and other institutions, provide new insights into the structure of chromatin and its implications for cellular differentiation.  The new work, appearing in …

25
Apr

New Insights into G Protein-Coupled Receptor Signaling and Regulation

A collaborative study by the laboratories of Jeffrey L. Benovic, PhD,  in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University and the Sidney Kimmel Cancer Center at Jefferson, and Dr. Brian K. Kobilka in the Department of Molecular and Cellular Physiology at the Stanford University School of Medicine provides new insights into a …

5
Apr

Promising New Results in Lung Cancer Research

Investigators at the Sidney Kimmel Cancer Center at Jefferson have uncovered a new regulatory pathway with important implications for lung cancer. Lung cancer is the leading cause of all cancer-related deaths worldwide, with 85% of all cases consisting of non-small cell lung cancer (NSCLC). A major obstacle to successfully treating NSCLC  is that many patients …

30
Mar

2017 Ocular Melanoma Foundation–AACR Fellowship Awarded to Vivian Chua

The Sidney Kimmel Cancer Center at Jefferson is pleased to announce that Vivian Chua, PhD, has been awarded a 2017 Ocular Melanoma Foundation–American Associate for Cancer Research (AACR) Fellowship for her project, “Novel Epigenetic Targeting Approaches in Uveal Melanoma.” This one-year, $50,000 grant recognizes the significant impact of Dr. Chua’s research, its relevance to the …

15
Mar

RNA-Regulated Mechanism Validated as a Target in GI Tract Cancers

Investigators from the Sidney Kimmel Cancer Center at Jefferson, Thomas Jefferson University, and Drexel University have uncovered a critical regulatory mechanism involved in pancreatic and colorectal cancer progression. The study results were recently published in Molecular Cancer Research. The researchers investigated the role of the RNA-binding protein HuR (also known as ELAVL1) in gastrointestinal (GI) …

17
Feb

Researchers Build Pan-Cancer Biomarker Tool to Categorize Multiple Cancer Types

Researchers at the Sidney Kimmel Cancer Center at Jefferson recently discovered that isomiRs (small non-coding RNA molecules produced in a cell) are powerful enough to accurately classify samples that can belong to 32 types of cancer. The research was published in the journal Nucleic Acids Research. Work in recent years has revealed that microRNAs (miRNAs), small …

21
Nov

Dr. Sara Meyer Joins Sidney Kimmel Cancer Center

The Sidney Kimmel Cancer Center at Jefferson is pleased to announce the appointment of Sara Meyer, PhD, as a new assistant professor in the department of Cancer Biology effective November 1, 2016. Previously, Dr. Meyer was a postdoctoral fellow at Cincinnati Children’s Hospital Medical Center. Dr. Meyer received her PhD in Cell and Molecular Cancer …

26
Oct

Dr. Grace Lu-Yao Joins Jefferson

Grace Lu-Yao, PhD, MPH, recently joined the Sidney Kimmel Cancer Center at Jefferson as part of the center’s growing population science program. She is now serving as the Associate Director for Population Science at the Sidney Kimmel Cancer Center at Jefferson and the Vice Chair and professor in the department of medical oncology at the …

13
Sep

2016 ASTRO Annual Meeting

The American Society for Radiation Oncology (ASTRO) Annual Meeting is the premier radiation oncology scientific event in the world and draws more than 11,000 attendees each year. The 2016 Annual Meeting, taking place Sept. 25-28 at the Boston Convention and Exhibition Center, will feature research from various members of the department of radiation oncology at …

30
Nov

Dr. Den Featured in ASCOPost: Genomic Test Identifies Patients With Prostate Cancer in Need of Intensified Salvage Therapy

Prostate cancer has been slow to catch up with breast cancer in terms of using biomarkers, but a new study represents progress in this regard. A genomic classifier called Decipher® provides important information that can be used to make treatment decisions for men with prostate cancer and a rising prostate-specific antigen (PSA) after radical prostatectomy. …

9
Nov

The Perfect Match Might Be the Imperfect One

When it comes to treating blood cancers like leukemia and lymphomas, new research shows that a half-matched donor bone marrow transplant may be just as good as a full match, in the first apples to apples type comparison of its kind. (PHILADELPHIA) – Bone marrow transplantation is a life-saving therapy for many patients with blood …

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