5
May

Getting Personal about Inherited Risk for Prostate Cancer

A new study published in JCO Precision Oncology by lead investigator Veda N. Giri, MD, at the Sidney Kimmel Cancer Center at Jefferson takes an important step in deciphering the genetic landscape contributing to inherited prostate cancer. Genetic Evaluation of Men (GEM) is a study focused on uncovering the genetic contribution to inherited prostate cancer. …

1
May

Dr. Veda Giri Featured on Congressional Directed Medical Research Programs Website

The research of Sidney Kimmel Cancer Center investigator Veda Giri, MD, has been highlighted on the Congressionally Directed Medical Research Programs (CDMRP) website. Giri and her team received funding from the U.S. Department of Defense Prostate Cancer Research Program (PCRP) to conduct studies on men at high risk for aggressive prostate cancer.  She and her …

28
Apr

Opening Up Chromatin for Cell Differentiation

Two new studies from the laboratory of Alex Mazo, PhD, at the Sidney Kimmel Cancer Center, along with collaborators from SKCC, the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University, and other institutions, provide new insights into the structure of chromatin and its implications for cellular differentiation.  The new work, appearing in …

25
Apr

New Insights into G Protein-Coupled Receptor Signaling and Regulation

A collaborative study by the laboratories of Jeffrey L. Benovic, PhD,  in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University and the Sidney Kimmel Cancer Center at Jefferson, and Dr. Brian K. Kobilka in the Department of Molecular and Cellular Physiology at the Stanford University School of Medicine provides new insights into a …

5
Apr

Promising New Results in Lung Cancer Research

Investigators at the Sidney Kimmel Cancer Center at Jefferson have uncovered a new regulatory pathway with important implications for lung cancer. Lung cancer is the leading cause of all cancer-related deaths worldwide, with 85% of all cases consisting of non-small cell lung cancer (NSCLC). A major obstacle to successfully treating NSCLC  is that many patients …

30
Mar

2017 Ocular Melanoma Foundation–AACR Fellowship Awarded to Vivian Chua

The Sidney Kimmel Cancer Center at Jefferson is pleased to announce that Vivian Chua, PhD, has been awarded a 2017 Ocular Melanoma Foundation–American Associate for Cancer Research (AACR) Fellowship for her project, “Novel Epigenetic Targeting Approaches in Uveal Melanoma.” This one-year, $50,000 grant recognizes the significant impact of Dr. Chua’s research, its relevance to the …

15
Mar

RNA-Regulated Mechanism Validated as a Target in GI Tract Cancers

Investigators from the Sidney Kimmel Cancer Center at Jefferson, Thomas Jefferson University, and Drexel University have uncovered a critical regulatory mechanism involved in pancreatic and colorectal cancer progression. The study results were recently published in Molecular Cancer Research. The researchers investigated the role of the RNA-binding protein HuR (also known as ELAVL1) in gastrointestinal (GI) …

17
Feb

Researchers Build Pan-Cancer Biomarker Tool to Categorize Multiple Cancer Types

Researchers at the Sidney Kimmel Cancer Center at Jefferson recently discovered that isomiRs (small non-coding RNA molecules produced in a cell) are powerful enough to accurately classify samples that can belong to 32 types of cancer. The research was published in the journal Nucleic Acids Research. Work in recent years has revealed that microRNAs (miRNAs), small …

21
Nov

Dr. Sara Meyer Joins Sidney Kimmel Cancer Center

The Sidney Kimmel Cancer Center at Jefferson is pleased to announce the appointment of Sara Meyer, PhD, as a new assistant professor in the department of Cancer Biology effective November 1, 2016. Previously, Dr. Meyer was a postdoctoral fellow at Cincinnati Children’s Hospital Medical Center. Dr. Meyer received her PhD in Cell and Molecular Cancer …

26
Oct

Dr. Grace Lu-Yao Joins Jefferson

Grace Lu-Yao, PhD, MPH, recently joined the Sidney Kimmel Cancer Center at Jefferson as part of the center’s growing population science program. She is now serving as the Associate Director for Population Science at the Sidney Kimmel Cancer Center at Jefferson and the Vice Chair and professor in the department of medical oncology at the …

13
Sep

2016 ASTRO Annual Meeting

The American Society for Radiation Oncology (ASTRO) Annual Meeting is the premier radiation oncology scientific event in the world and draws more than 11,000 attendees each year. The 2016 Annual Meeting, taking place Sept. 25-28 at the Boston Convention and Exhibition Center, will feature research from various members of the department of radiation oncology at …

30
Nov

Dr. Den Featured in ASCOPost: Genomic Test Identifies Patients With Prostate Cancer in Need of Intensified Salvage Therapy

Prostate cancer has been slow to catch up with breast cancer in terms of using biomarkers, but a new study represents progress in this regard. A genomic classifier called Decipher® provides important information that can be used to make treatment decisions for men with prostate cancer and a rising prostate-specific antigen (PSA) after radical prostatectomy. …

9
Nov

The Perfect Match Might Be the Imperfect One

When it comes to treating blood cancers like leukemia and lymphomas, new research shows that a half-matched donor bone marrow transplant may be just as good as a full match, in the first apples to apples type comparison of its kind. (PHILADELPHIA) – Bone marrow transplantation is a life-saving therapy for many patients with blood …

29
Oct

Dr. Robert Den featured in ASCO Post

For men with prostate cancer who have had a prostatectomy and salvage radiation therapy, analyzing their tumor genome provides clues as to whether their cancer will metastasize, thereby enabling clinicians to better personalize treatment options, according to research presented by Robert Den, MD.  ASTRO 2015: Genomic Classifier Appears to Predict Metastasis in Patients With Prostate …

26
Jun

Dr. Andrew Aplin Receives New NIH/NCI R01 Grant Award

Congratulations to Dr. Andrew Aplin for receiving a federally award (National Institute of Health/National Cancer Institute) R01 grant for his project: Mutant BRAF-regulated transcription factors in melanoma progression.

14
Apr

Dr. Myers Invited To Share His Research At Preventive Oncology Meeting

Ronald Myers, PhD, Professor of Medical Onocology, was invited to share his work on CRC screening as one of 3 “Best of CEBP” presentations at the recent American Society for Preventive Oncology 39th Annual Meeting in Birmingham, Alabama on March 16, 2015. For more about the ASPO meeting see the agenda  

14
Apr

SKCC Scientists Show That Cancer Cells Can Use Exosome Transfer To Pass On Agressive Traits

Until recently, researchers thought that cell division was the only way for an aggressive cancer cell to pass its traits along. New evidence is showing that cancers can become more dangerous by exporting aggressive traits to neighboring cells via exosomes. These small packages — bubbles — of membrane released into the extracellular environment hold pieces …

17
Feb

New genomic test can direct appropriate use of radiation therapy following prostate surgery

The identification of the right patients for post-operative radiation therapy and the timing of administering that therapy are not easily answered by clinical risk factors alone. The study, published in the Journal of Clinical Oncology, showed that patients with low genomic risk may be optimally managed with observation after radical prostatectomy (prostate surgery), while those …

17
Feb

Dr. William Kevin Kelly appointed leader of the Biology of Prostate Cancer Program

The Sidney Kimmel Cancer Center would like to congratulate Wm. Kevin Kelly, D.O., Professor of Medical Oncology and Director of the Division of Solid Tumor Oncology, on his new appointment as the Leader of the Biology of Prostate Cancer Program.  Dr. Kelly has been a considerable asset to the cancer center and Jefferson as a …

10
Feb

Dr. Andrew Aplin to Lead Basic Science of the Sidney KImmel Cancer Center

Congratulations to Andrew Aplin, PhD, for his appointment to lead Basic Science for the SKCC! Dr. Aplin has already distinguished himself as the leader of the Cancer Cell Biology and Signaling Program, and he will bring his energy and scientific expertise to all aspects of basic research here at the Sidney Kimmel Cancer Center. Please …

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