Archives

22
Mar

Team Jefferson at 2013 Get Your Rear in Gear Race

Supporters of the Kimmel Cancer Center joined “Team Jefferson” for this year’s Get Your Rear in Gear 5K and 10K runs, 2 mile walk or a kids’ fun run. Proceeds support cutting edge research in colorectal cancer and compassionate care. Maria Grasso, founder and organizer of GYRIG Philadelphia, presented a check to Jefferson from last …

22
Mar

Jefferson Graduate Student Receives 2013 Joanna M. Nicolay Melanoma Foundation Award

Curtis Kugel, a Thomas Jefferson University graduate student in the Department of Cancer Biology, was one of 10 students from leading cancer centers across the U.S. to receive a $10,000 “Research Scholar Award” (RSA) from the Joanna M. Nicolay Melanoma Foundation (JMNMF) for his exceptional research work. JMNMF Chair, Regina Shannon Bodnar, and Board/RSA Committee …

6
Mar

Remembering ASCO Founding Member Dr. Jane Cooke Wright

In February, the American Society of Clinical Oncology (ASCO) announced the passing of Jane Cooke Wright, M.D., a true pioneer, mentor, and renowned researcher. Dr. Wright was one of seven founding members of ASCO – the only woman among the founders – and the Society’s first Secretary/Treasurer. She died on Tuesday, February 19 at the …

12
Feb

Massimo Cristofanilli, M.D., Appointed Director of the Jefferson Breast Care Center

Massimo Cristofanilli, M.D., FACP, an internationally renowned breast cancer researcher and clinician, has been appointed Director of the Jefferson Breast Care Center at the Kimmel Cancer Center (KCC) and Thomas Jefferson University and Hospitals. With more than 25 years of clinical, basic science and educational experience, Dr. Cristofanilli will also serve as Deputy Director of …

12
Feb

Jefferson Opens Calorie Restriction Trial for Early Stage Breast Cancer Patients on Radiation Therapy

Jefferson’s Kimmel Cancer Center will begin a first-of-its-kind clinical trial that uses calorie restriction to help treat early stage breast cancer patients undergoing radiation therapy. Evidence suggests that reducing patients’ calorie intake could help shrink tumors and improve survival because it enhances the effectiveness of radiation therapy, the team explains in a recent review published …

12
Feb

Jefferson Radiation Oncology Resident Looks to Improve Prostate Cancer Outcomes in Ghana

A new study published in January in the journal BMC Cancer, led by Kosj Yamoah, M.D., Ph.D., a resident in the Department of Radiation Oncology at Thomas Jefferson University and Hospital, takes aim at the issue by investigating prostate cancer diagnoses and treatment delivery in black men living in the West African region, in order …

12
Feb

Phone and Mailed Interventions Significantly Increase Colorectal Cancer Screening Rates

A mailing or phone call to help patients get screened for colorectal cancer significantly increases their chances of actually getting tested, according to a study published in the January issue of Cancer Epidemiology, Biomarkers and Prevention by researchers at the Kimmel Cancer Center at Jefferson. The research team, led by Ronald E. Myers, Ph.D., Professor …

12
Feb

Radiation Oncology Services Expanding at Riddle Hospital

Jefferson Radiation Oncology at Riddle Memorial Hospital is pleased to announce that the expansion of Radiation Oncology services has begun. In the next few months, the Department will begin installing a new True –Beam linear accelerator, Brachytherapy High Dose Rate machine and a CT scanner. Construction is expected to be completed by December 2013. The acquisition of this …

16
Jan

Karen Knudsen, Ph.D., Appointed Deputy Director of Basic Science at Thomas Jefferson University

Thomas Jefferson University and the Kimmel Cancer Center are pleased to announce that Karen E. Knudsen, Ph.D., has accepted the position as Deputy Director of Basic Science, and will hold the prestigious Hilary Koprowski Chair in the Department of Cancer Biology. Dr. Knudsen received her Ph.D. from the University of California at San Diego in …

9
Jan

Bench to Bedside: How to Fast Track Targeted Cancer Drugs with Radiation into the Clinic

Researchers from the translational research program of the National Cancer Institute and the Radiation Therapy Oncology Therapy Group have developed new guidelines to help fast track the clinical development of targeted cancer drugs in combination with radiation therapy. The suggested strategic guidelines, published in the Journal of the National Cancer Institute in a recent commentary …

8
Jan

More Designated Time Equals More Published Research for Radiation Oncology Residents

What helps radiation oncologist residents publish more academic research? Giving them more time to do it, physicians in the Department of Radiation Oncology at Thomas Jefferson University Hospital conclude in a study published recently in the Journal of American College of Radiology. Based on results from a web-based survey completed by 97 radiation oncologists and …

21
Dec

Game changing diagnostic & prognostic prostate cancer genetic tests revealed by KCC researchers

Researchers at the Kimmel Cancer Center at Jefferson (KCC) have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers. The team, led by Richard G. Pestell, M.D., Ph.D., Director of the KCC and the Chair of the Department of Cancer Biology at Thomas Jefferson …

21
Dec

KCC researchers discover new pathways that drive metastatic prostate cancer

Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on December 21 in the Journal of Clinical Investigation by researchers at the Kimmel Cancer Center at Jefferson. The group, headed by Karen E. Knudsen, Ph.D., Professor …

19
Dec

Edith Mitchell Appointed to NCI’s Clinical Trials & Translational Research Advisory Committee

Edith P. Mitchell, M.D., FACP, a medical oncologist at Thomas Jefferson University Hospital and Clinical Professor of Medicine and Medical Oncology in the Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, has been appointed to the National Cancer Institute’s Clinical Trials and Translational Research Advisory Committee. The committee makes recommendations on …

4
Dec

Jefferon’s Kimmel Cancer Center Holds 4th Annual Men’s Event

Jefferson’s Kimmel Cancer Center hosted its 4th Annual Men’s Event to benefit prostate cancer research and awareness at the Prime Rib Restaurant on November 15. Guests enjoyed cocktails, dinner, auctions, and entertainment from special guest Jay Mohr. The event grossed over $200,000. Below are some photos of the night, award ceremony and stand up act …

15
Nov

Karen E. Knudsen Named New Editor-in-chief of AACR Journal Molecular Cancer Research

The American Association for Cancer Research is pleased to announce Karen E. Knudsen, Ph.D., professor and Hilary Koprowski chair in the departments of cancer biology, urology and radiation oncology at Thomas Jefferson University in Philadelphia, and deputy director for basic science of the NCI-designated Kimmel Cancer Center as the new editor-in-chief of Molecular Cancer Research, …

31
Oct

New Ocular Melanoma Research Grant in Honor of David Eschelman

The Community United for Research and Education of Ocular Melanoma, or CURE OM, recently announced a new research grant in honor of Dr. David Eschelman of Thomas Jefferson University’s Department of Radiology specifically for the study of ocular melanoma. Uveal melanoma, also known as ocular melanoma (OM), is diagnosed in about 2,000 people a year …

23
Oct

Dr. Renato Iozzo appointed as Editor-In-Chief of Matrix Biology

Renato Iozzo, M.D., Ph.D.,  a Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University, has recently been appointed as Editor-in-Chief of the journal Matrix Biology beginning January 2013. This flagship journal is published by Elsevier and is affiliated with both the International Society for Matrix Biology and the American Society for Matrix Biology. …

22
Oct

NCI Awards ‘Provocative Questions’ Grant to Thomas Jefferson University Researcher Scott Waldman

Scott Waldman, M.D., Ph.D., chairman of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been awarded one of the prestigious “Provocative Questions”  grants from the National Cancer Institute (NCI) , as part of the Institute’s ambitious program to tackle the “important but not obvious” questions in cancer to ensure no stone …

19
Oct

The Kimmel Cancer Center Remembers the Late Sen. Arlen Specter

The Kimmel Cancer Center at Jefferson is remembering longtime proponent of cancer research Senator Arlen Specter, who passed away on Oct. 14 at the age of 82, after a battle with non-Hodgkin lymphoma. On the Senate Appropriations Committee, Sen. Specter led the fight to increase funding for the National Institutes of Health from $12 to …

16
Oct

Stat5 Predicts Outcomes for Prostate Cancer Patients after Radical Prostatectomy

Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson’s Kimmel …

15
Oct

Kimmel Cancer Center to Host 4th Annual Men’s Event with Special Guest Jay Mohr

Jefferson’s Kimmel Cancer Center will host its 4th Annual Men’s Event at the Prime Rib in Philadelphia, with Special Guest Jay Mohr, comedian, actor, radio host, best-selling author and of Saturday Night Live and Jerry Maguire fame. The event will take place on Thursday, November 15 from 5:30 p.m. to 9:00 p.m at the Prime …

9
Oct

Doubling up on Advanced Prostate Cancer with PARP Inhibitors

A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson’s Kimmel Cancer Center researchers suggests. The team, led by Karen E. Knudsen, Ph.D., Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology at …

28
Sep

KCC’s New Magazine “Milestones” is Now Available

Jefferson’s Kimmel Cancer Center announces its first issue of “Milestones,” an online magazine covering breakthrough research, faculty, clinical updates, events and all things KCC. This issue’s cover story delves into the latest advances in cancer genomics and how researchers are transforming cancer treatment with focused genomics. “The work of Dr. Paolo Fortina and the staff …

20
Sep

Tissue around tumor holds key to fighting triple negative breast cancer

A natural substance found in the surrounding tissue of a tumor may be a promising weapon to stop triple negative breast cancer from metastasizing. A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of tumor …

14
Sep

Jefferson and the Eagles Team Up for Prostate Health and Cancer Awareness

September is Prostate Cancer Awareness month, and Thomas Jefferson University Hospitals has again teamed up with the Philadelphia Eagles to educate fans and others about prostate health and to raise cancer awareness. To help kick off the campaign, Jefferson will serve as the presenting partner at the Sunday, September 16 game versus the Baltimore Ravens, with …

13
Sep

KCC Becomes Provisional ECOG Member

In August, The Eastern Cooperative Oncology Group (ECOG) voted to approve Jefferson’s Kimmel Cancer Center and Thomas Jefferson University Hospital as a Provisional Member. ECOG is one of the largest clinical cancer research organizations in the United States, and conducts clinical trials in all types of adult cancers. It constitutes a large network of private …

6
Sep

Dr. Onder Alpdogan and Dr. Jianqing Lin Granted ACS-IRG Awards

Congratulations to Dr. Onder Alpdogan and Dr. Jianqing Lin for each being selected recipients of an ACS-IRG award. The American Cancer Society-Institutional Research Grants (ACS-IRG) are designed to provide seed money to support junior faculty members with an interest in cancer research. The ACS defines junior faculty as investigators at the rank of assistant professor …

5
Sep

Voichita Bar-Ad, M.D., Named Residency Program Director in Jefferson’s Radiation Oncology Department

Voichita Bar-Ad, M.D., an associate professor in the Department of Radiation Oncology at Thomas Jefferson University Hospital and Jefferson’s Kimmel Cancer Center, has been named Residency Program Director. Dr. Bar-Ad is a board-certified radiation oncologist who treats primarily head and neck and gastrointestinal cancer cases. Her research focuses on treatment-related side effects and toxicities, patient quality …

1
Aug

Nicole Simone, M.D., Receives ASTRO Research Award

The American Society for Radiation Oncology (ASTRO) has awarded five physicians with research grants to promote the continued advancement of radiation therapy. One of this year’s recipient for the Junior Faculty Career Research Training Award is Nicole L. Simone, M.D., of the Department of Radiation Oncology at Thomas Jefferson University Hospital. The Junior Faculty Award …

26
Jul

Breast Cancer Patients Who Lack RB Gene Respond Better to Neoadjuvant Chemotherapy

Breast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research. Many breast cancer patients undergo neoadjuvant therapy …

17
Jul

Thomas Jefferson University Hospital Ranked Among Best for Cancer by U.S. News & World Report

Thomas Jefferson University Hospital has again been ranked as one of the nation’s best hospitals for cancer care by the U.S. News & World Report, coming in at No. 20 in the 2012 Best Hospitals survey. Last year, Jefferson ranked 31st in the nation for cancer. In addition, the hospital was ranked number three in …

28
Jun

ATP: From Bystander to Actor in Kinase Regulation

A new function of ATP—beyond its passive roles as an energy source and a phosphate donor for phosphorylation reactions—was unraveled by Jefferson researchers. Their studies revealed a new model of kinase regulation, whereby ATP modulates an “on-off-switch” mechanism in Akt by inducing conformational changes in the Akt kinase domain. The three members of the Akt …

14
Jun

How Aging Normal Cells Fuel Tumor Growth and Metastasis

It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of …

14
Jun

Kimmel Cancer Center at Jefferson Hosts a Patient Symposium Focusing on Melanoma of the Eye

The Kimmel Cancer Center will host the inaugural “Eyes on a Cure: Patient and Caregiver Symposium”  on June 16 and 17. The symposium will bring uveal melanoma patients, caregivers, and researchers from around the world together to offer educational sessions, support groups led by oncology social workers, sessions on complementary therapies, as well as informal …

7
Jun

HIV drug may slow down metastatic breast cancer

The HIV drugs known as CCR5 antagonists may also help prevent aggressive breast cancers from metastasizing, researchers from the Kimmel Cancer Center at Jefferson suggest in a preclinical study published in a recent issue of Cancer Research. Such drugs target the HIV receptor CCR5, which the virus uses to enter and infect host cells, and …

31
May

ASCO: Younger Colon Cancer Patients Have Worse Prognosis at Diagnosis, Yet Better Survival

Younger patients with colorectal cancer were more likely to present advanced stage tumors at diagnosis and metastasize much sooner, yet had better than or equal survival to patients 50 and older, according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract #3621, Monday, June 4, 8:00 AM …

31
May

ASCO: Liver Metastases and its Prognostic Significance in Men With Metastatic Castration-Refractory Prostate Cancer

Liver metastases predicts shorter overall survival in men with metastatic castration-refractory prostate cancer (mCRPC), according to data being presented at the 2012 American Society of Clinical Oncology Annual Meeting in Chicago. (Abstract # 4655, Sunday, June 3, 8:00 AM – 12:00 PM CST, S Hall A2). In a phase III trial, lead study author William …

23
May

Data Continues to Support Provenge’s Overall Survival Benefit in Prostate Cancer Patients

This article was adapted from an OncLive story posted on May 21, 2012. Leonard G. Gomella, M.D, chair of the Department of Urology at Thomas Jefferson University Hospital and director of Clinical Affairs, Jefferson’s Kimmel Cancer Center, was part of the team to present new findings from the IMPACT trial looking at the immunotherapy sipuleucel-T …

22
May

Jefferson’s Kimmel Cancer Center to Host Tribute Dinner Honoring Steve Sabol, President of NFL Films

Jefferson’s Kimmel Cancer Center will host a tribute dinner to honor legendary filmmaker Steve Sabol, President of NFL Films, with the Spirit of Courage Award at the Union League of Philadelphia on June 5. The award is presented to an individual who has demonstrated great personal courage, strength and dignity while battling cancer and supporting …

16
May

Jefferson Receives $2.6 Million NIH Grant to Study Imaging Method to Stage Prostate Cancer Without Biopsy

Jefferson’s Kimmel Cancer Center and the Department of Radiology at Thomas Jefferson University received a five-year, $2.6 million grant from the National Institutes of Health (NIH) to investigate a potentially revolutionary method that can stage prostate cancers and detect recurrent disease so accurately, it would significantly reduce the number of confirmation biopsies. Such biopsies can …

10
May

A Closer Look at PARP-1 Reveals Potential New Drug Targets

A new study published in Science May 11 is shedding light on the molecular details of PARP-1, a DNA damage-detecting enzyme that when inhibited has been shown to be effective in fighting cancer and other diseases. The investigation led by John M. Pascal, Ph.D., an assistant professor in the Department of Biochemistry and Molecular Biology …

26
Apr

Scott Waldman Awarded CURE Grant to Move Colon Cancer Test Closer to Commercialization

Scott Waldman, M.D., Ph.D., Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been awarded a Commonwealth Universal Research Enhancement (CURE) grant for almost $750,000 to help advance a molecular diagnostic test for colon cancer into commercialization. Such a test would better detect recurrence in a group of colon cancer …

25
Apr

You Can Help Save PA Research Funding

For more than a decade, Pennsylvania’s Commonwealth Universal Research Enhancement Program (CURE) has supported a broad range of biomedical research at 39 institutions across Pennsylvania. These funds have led to research advances in cancer, cardiovascular disease, diabetes, infectious diseases, and other health areas and improvements in public health. In his budget for fiscal year 2013, …

19
Apr

Dawn Scardino named 2012 LLS Woman of the Year

Dawn Scardino, Coordinator of Academic Services in the Department of Medical Oncology, was named the 2012 Leukemia & Lymphoma Society’s Woman of the Year for the eastern Pennsylvania Chapter. Dawn took the top recognition for raising almost $27,000 in a 10-week fundraising “race” that began on Jan. 30 and ended on April 12.  Four women …

12
Apr

Leading the Way to a Cure

It is estimated that more than 70,000 new cases of bladder cancer were diagnosed in 2011, making it the fifth most commonly diagnosed cancer in the U.S. Please join Team Jefferson and Dr. Jean Hoffman-Censits of the Department of Medical Oncology, Solid Tumor Division and the Kimmel Cancer Center at Jefferson in raising awareness of …

5
Apr

Edith Mitchell, M.D., FACP, Named 2012 Recipient of ASCO Humanitarian Award

Edith  Mitchell, M.D., FACP, a medical oncologist at Thomas Jefferson University Hospital and Jefferson’s Kimmel Cancer Center (KCC) and Clinical Professor of Medicine and Medical Oncology in the Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, has been named the 2012 recipient of the American Society of Clinical Oncology (ASCO) Humanitarian …

5
Apr

Ovarian, Glioblastoma & Non-Small Cell Lung Cancer: Jefferson Researchers Present at AACR

Several researchers from Jefferson’s Kimmel Cancer Center presented abstracts at the American Association for Cancer Research Annual Meeting 2012 in Chicago. Some of those findings include: HuR and Ovarian Cancer Silencing HuR may be a promising therapeutic approach for the treatment of ovarian cancer, according to an abstract presented at AACR by researchers from Thomas …

3
Apr

AACR: New Biomarker to Identify Hepatitis B-Infected Patients at Risk for Liver Cancer

CHICAGO— Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson’s Kimmel Cancer Center at the American Association for Cancer Research (AACR) …

3
Apr

AACR: Eliminating the ‘Good Cholesterol’ Receptor May Fight Breast Cancer

CHICAGO— Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson’s Kimmel Cancer Center researchers. In vitro and mouse studies revealed that depletion of the SR-BI resulted in a decrease in breast cancer cell …

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