14
Dec

New Recommendations Provide Guidance on Genetic Counseling & Testing for Hereditary Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. Now, an international and interspecialty panel of experts convened at the Sidney Kimmel Cancer Center (SKCC) at Jefferson have developed a comprehensive set of recommendations. This consensus statement, published December 13th in the Journal …

13
Dec

Scott Waldman Named a 2017 Fellow of the National Academy of Inventors

Scott A. Waldman, MD, PhD, Co-Leader of the Gastrointestinal Cancer Program at the Sidney Kimmel Cancer Center at Jefferson and Chair of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been named a Fellow of the National Academy of Inventors (NAI). Waldman is a leader in clinical pharmacology, whose groundbreaking research …

11
Dec

Sidney Kimmel Cancer Center Researchers Receive $1.3 Million from Falk Trust

How can doctors use immunotherapy to develop more effective and durable anticancer therapies? Is it possible to return aggressive cancer cells to a dormant form once they have spread? Those are two questions SKCC researchers Andrew Aplin, PhD, and Emad Alnemri, PhD, will explore with $1.3 million in grants from the Dr. Ralph and Marian …

5
Dec

Researchers Find Breakthroughs in Understanding Genetic Basis of Aggressive Prostate Cancer

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer. When it was removed or damaged, cancer thrived. Over the years, researchers have discovered methods that have allowed them to experimentally remove the RB gene in order to study it, but just how the gene’s loss made cancers more aggressive was poorly understood. By studying patient samples, …

28
Nov

Decoding the Molecular Mechanisms of Ovarian Cancer Progression

A new study from Sidney Kimmel Cancer Center (SKCC) investigator Christine Eischen, PhD, provided important new insights into the mechanisms contributing to ovarian cancer. The findings were recently published in Nature Communications. Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 …

21
Nov

Cancer Cell Signaling: Selecting the Best Importin for the Job

New research from Sidney Kimmel Cancer Center at Jefferson member Gino Cingolani, PhD, recently provided critical insights into the nuclear import of key signaling proteins, including those involved in tumorigenesis. For a vast array of cellular processes, numerous proteins must be imported and exported from the cell nucleus in a tightly regulated fashion. Typically, proteins that …

20
Nov

CyberKnife Provides Long-term Disease Control for Prostate Cancer Patients

Jefferson now offers treatment with the CyberKnife® System, a noninvasive alternative to surgery for treating cancerous and noncancerous tumors, which has been shown to provide excellent long-term results for patients with low-and intermediate-risk prostate cancer. According to a recent national 17-center study, after 10 years 98.4 percent of the 230 men monitored with low-risk prostate cancer who were treated with the …

17
Nov

Christine Eischen Receives 2017 AACR-Bayer Innovation and Discovery Grant

Christine M. Eischen, PhD, Co-Leader of the Molecular Biology & Genetics Program at the Sidney Kimmel Cancer Center at Jefferson, has been awarded a 2017 AACR-Bayer Innovation and Discovery Grant. Her grant is entitled, “Using PROTACS to target the Mdm2 oncoprotein.” The Innovation and Discovery Grant offers one-year grants to “meritorious projects that examine important, and …

7
Nov

Sidney Kimmel Cancer Center Grand Rounds Lecture: Elizabeth A. Platz

The Sidney Kimmel Cancer Center at Jefferson is pleased to welcome Elizabeth A. Platz, ScD, MPH, as this week’s lecturer in our Grand Rounds Series. Her talk is entitled “Population Science: Collaborating to Uncover Cancer Etiology While Reflecting on Translation to Reduce Cancer Burden.” Dr. Platz is a Professor, Martin D. Abeloff, MD Scholar in …

19
Oct

Knudsen and Kelly Receive NCI Funding

Two Sidney Kimmel Cancer Center investigators, Karen Knudsen, PhD, and Wm. Kevin Kelly, DO, have been awarded a new R01 grant from the National Cancer Institute to develop more effective therapeutic strategies for advanced prostate cancer. The project builds on previous discoveries from these investigators that identified specific cell cycle alterations in metastatic castrate-resistant prostate cancer and …

13
Oct

Ayesha Shafi receives PCF Young Investigator Award

Ayesha Shafi, PhD, a postdoctoral researcher in the laboratory of Sidney Kimmel Cancer Center Director Dr. Karen Knudsen, has been awarded a prestigious Prostate Cancer Foundation (PCF) Young Investigator Award. Shafi is conducting research on the role of the androgen receptor and the DNA repair factor DNA-dependent protein kinase in prostate cancer. Her studies are …

13
Oct

Elda Grabocka Recipient of V Foundation Scholar Research Award

Congratulations to Elda Grabocka, PhD, who has been given a prestigious V Foundation Scholar Research Award. Her grant, entitled “Targeting Stress Adaptive Mechanisms as a Strategy for Precision Oncology in Pancreatic Cancer,” is focused on investigating stress granules as predictors of drug resistance and as effective therapeutic targets for the treatment of KRAS-driven pancreatic cancer. …

19
Sep

Molecular Profiling of Key Survival Proteins in B-cell Lymphoma Subtypes

Investigators at the Sidney Kimmel Cancer Center at Jefferson uncovered potential new culprits that contribute to the development and progression of several types of lymphoma. The study was published in a recent issue of Clinical Cancer Research, with co-first authors Drs. Clare M. Adams and Ramkrishna Mitra, along with co-author Dr. Jerald Z. Gong and senior author Christine …

18
Aug

Colorectal Cancer Metastasis: A Game of Clones

Colorectal cancer is highly prevalent worldwide, and metastasis of colorectal cancer to distant sites accounts for ~90% of the mortality associated with this disease. Researchers at the Sidney Kimmel Cancer Center at Jefferson (SKCC), along with collaborators at several other institutions, tracked genomic changes that occur as colorectal tumors progress and metastasize to distant sites …

10
Aug

Cancer Immunotherapy Might Come with a Hidden Cost

Recent findings from investigators at the Sidney Kimmel Cancer Center at Jefferson raise potential concerns regarding adverse effects associated with a therapeutic approach that has revolutionized the field of cancer treatment — cancer immunotherapy. The findings were recently published in the International Journal of Radiation Oncology + Biology + Physics. In immunotherapy, clinicians harness the power of …

9
Aug

Thomas Jefferson University Hospital (Sidney Kimmel Cancer Center at Jefferson) Ranked No. 20 in the Nation for Cancer

Thomas Jefferson University Hospital (Sidney Kimmel Cancer Center at Jefferson) has been nationally ranked No. 20 in the cancer specialty for 2017-2018 by U.S. News & World Report. U.S. News & World Report Best Hospitals rankings recognize hospitals that treat the most challenging patients and evaluate each hospital’s use of advanced technologies, safety, outcomes, and …

4
Aug

Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer

New research from investigators at the Sidney Kimmel Cancer Center at Jefferson provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. The study was recently published online in Cancer Research. The research team studied the role of an RNA-binding protein termed HuR in influencing the …

2
Aug

Abington – Jefferson Health Recognized by NRG Oncology

Congratulations to Abington – Jefferson Health, who was recently announced as the #3 top accruing Main Member site for Fiscal Year 2017 by NRG Oncology. The announcement was made at the NRG Oncology Semiannual Meeting, held July 13-15, 2017 in Philadelphia. NRG Oncology seeks to improve the lives of patients with cancer by conducting practice-changing …

26
Jul

Single-Cell Resolution Mutational Profiling in Breast Cancer

A new study from Sidney Kimmel Cancer Center at Jefferson demonstrated the feasibility of detecting cancer-associated gene mutations in circulating tumor cells (CTC) isolated from patients — providing a powerful new tool for clinicians and cancer researchers. Published in Clinical Cancer Research, the project was led by senior authors Paolo M. Fortina, MD, PhD, and Massimo …

14
Jul

A Lifelong Dedication to Cancer

When Alison Petok was five years old, her Nana died of leukemia. “If she had been diagnosed a decade or two later, perhaps she would have survived due to the advances in blood cancer research,” Alison reflected. Years later in 2017, Alison was nominated as “Woman of the Year” by The Leukemia & Lymphoma Society …

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